引气归元针法联合涌泉穴艾灸治疗围绝经期失眠症疗效及对患者血清白细胞介素-1β、5-HT、FSH的影响

Clinical effect of acupuncture of Yinqi Guiyuan combined with moxibustion of Yongquan acupoint on patients with perimenopausal insomnia and effect on serum interleukin-1β,5-HT,FSH

目的:探究引气归元针法联合涌泉穴艾灸对围绝经期失眠症(MI)患者的临床疗效及对血清白细胞介素-1β(IL-1β)、5-羟色胺(5-HT)、促卵泡激素(FSH)的影响。方法:收治的MI患者106例作为研究对象,依据随机数字表法分为两组,各53例。对照组给予西医常规治疗,观察组在对照组基础上给予引气归元针法联合涌泉穴艾灸治疗,10 d为1个疗程,共治疗两个疗程。比较两组治疗效果、治疗前后睡眠进程[睡眠潜伏期(SL)、觉醒次数(AT)、觉醒时间(AWT)、REW睡眠潜伏期(RL)、睡眠效率(SE)]、睡眠结构[慢波睡眠(NREM)、快波睡眠(REM)]、睡眠质量(PSQI)评分、血清IL-1β、5-HT、FSH及安全性。结果:观察组治疗总有效率94.34%高于对照组75.47%,SL、AT、AWT、RL低于对照组,SE高于对照组(P<0.05)。治疗两个疗程后,观察组NREM S 1、S 2低于对照组,S 3+S 4、REM高于对照组(P<0.05)。治疗两个疗程后,观察组PSQI评分低于对照组(P<0.05)。治疗两个疗程后,观察组血清IL-1β、5-HT高于对照组,FSH低于对照组(P<0.05)。结论:引气归元针法联合涌泉穴艾灸治疗MI,可改善患者睡眠结构和进程,提高睡眠质量,疗效较好,其机制可能与调控IL-1β、5-HT、FSH有关。

Objective:To explore the clinical effect of the acupuncture of Yinqi Guiyuan combined with moxibustion at Yongquan point on patients with perimenopause insomnia(MI)and the effects of serum interleukin-1β(IL-1β),5-hydroxytryptamine(5-HT),and follicle stimulating hormone(FSH).Methods:A total of 106 patients with MI were divided into two groups,each with 53 cases.The control group was given conventional western medicine treatment,the observation group was given the Yinqi Guiyuan acupuncture combined with moxibustion at Yongquan on the basis of the control group,10 days was a course of treatment,a total of two courses of treatment.Compare the treatment effect,sleep progress[sleep latency(SL),number of awakenings(AT),wake time(AWT),REW sleep latency(RL),sleep efficiency(SE)],sleep structure[slow wave sleep(NREM),fast wave sleep(REM)],sleep quality(PSQI)score,serum IL-1β,5-HT,FSH and safety between the two groups.Results:The total effective rate in the observation group 94.34%was higher than that in the control group 75.47%,SL,AT,AWT,RL were lower than the control group,and SE was higher than the control group(P<0.05).After two courses of treatment,the NREM S 1 and S 2 in the observation group were lower than those in the control group,S 3+S 4 and REM were higher than the control group(P<0.05).After two courses of treatment,the PSQI score of the observation group was lower than that of the control group(P<0.05).After two courses of treatment,serum IL-1βand 5-HT in observation group were higher than those in the control group,and FSH was lower than those in control group(P<0.05).Conclusion:Acupuncture method of Yinqi Guiyuan combined with moxibustion of Yongquan acupuncture for MI,can improve the sleep structure and process of patients and sleep quality.It has significant curative effect,its mechanism may be related to the regulation of IL-1β,5-HT and FSH.