基于中医肿瘤疗效评价体系探讨扶正抗癌方对中晚期非小细胞肺癌细胞免疫功能的影响

Effect of Fuzheng Kangai decoction on the immune function of patients with middle-advanced non-small cell lung cancer based on the efficiency evaluation system of traditional Chinese medicine for tumor

目的基于中医肿瘤疗效评价体系探讨扶正抗癌方对中晚期非小细胞肺癌细胞免疫功能的影响。方法选取2016年10月—2018年5月陕西中医药大学附属医院收治的中晚期非小细胞肺癌一线治疗失败患者120例,随机分为2组,对照组60例采用DC方案治疗,治疗组60例采用扶正抗癌方联合DC方案治疗,治疗4个周期后,观察2组中医肿瘤疗效评价体系(瘤体变化^+临床症状^+体力状况^+生存期)和细胞免疫功能的变化。结果治疗后治疗组瘤体变化、临床症状、体力状况改善情况均优于对照组(P均<0.05)。治疗后治疗组总体疗效客观缓解率为88.3%(53/60),总有效率为51.7%(31/60),对照组分别为68.3%(34/60)和25.0%(15/60),2组比较差异均有统计学意义(P均<0.05)。对照组患者治疗2个和4个周期后外周血CD3^+、CD4^+、CD8^+逐渐下降,治疗组患者外周血CD3^+、CD4^+不断升高,CD8^+不断降低,但治疗组同期治疗后外周血CD3^+、CD4^+、CD8^+均显著高于对照组,差异均有统计学意义(P均<0.05)。结论扶正抗癌方可增强非小细胞肺癌患者的免疫力,改善患者的临床症状,提高患者的生活质量,有效控制疾病进展,为防止肿瘤复发和转移的有效方药。

Objective It is to explore the effect of Fuzheng Kangai decotion on the cellular immune function of patients with middle-advanced non-small cell lung cancer based on the efficiency evaluation system of traditional Chinese medicine for tumor.Methods 120 patients with middle-advanced non-small cell lung cancer who failed in first-line treatment treated in the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from October 2016 to May 2018 were randomly divided into 2 groups:60 patients in the control group were treated with DC regimen,and 60 patients in the treatment group were treated with Fuzheng Kangai decoction combined with DC regimen.After 4 cycles of treatment,the changes of the TCM tumor efficacy evaluation system(tumor body change^+clinical symptoms^+physical condition^+survival period)and cellular immune function were observed in the two groups.Results After treatment,the tumor body changes,improvements of clinical symptoms and physical condition of the treatment group were significantly better than those of the control group(P<0.05).After treatment,the overall response rate of the treatment group was 88.3%(53/60),the total effective rate was 51.7%(31/60),and those of the control group were 68.3%(34/60)and 25.0%(15/60)respectively.The differences in these rates between the two groups were statistically significant(P<0.05).After 2 and 4 cycles of treatment,the peripheral blood T cell subsets(CD3^+,CD4^+,and CD8^+)valueswere gradually decreased in the control group,the peripheral blood CD3^+,CD4^+values were continuously increased,and CD8^+was continuously decreased in the treatment group,the improvements of CD3^+,CD4^+and CD8^+valuesin peripheral blood of the control group were significantly higher than those of the control group at the same period of treatment,and the differences were statistically significant(P<0.05).Conclusion Fuzheng Kangai decotion could enhance immune function,improve clinical symptoms and quality of life and effectively control the development of disease in patients with middle-advanced non-small cell lung cancer,it is an effective prescription for preventing tumor recurrence and metastasis.