丙型肝炎病毒感染者胆囊疾病发生情况及临床分析

Occurrence and clinical analysis of gallbladder disease in patients infected with hepatitis C virus

目的研究丙型肝炎病毒(Hepatitis C virus,HCV)感染者胆囊疾病的发生情况及相关危险因素。方法依据彩色超声报告结果将290例HCV感染者分为有胆囊疾病组169例,无胆囊疾病组121例,分析病程、体重指数(BMI)、负性情绪、酗酒史、血清总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、γ-谷氨酞转肽酶(GGT)、血清白蛋白(ALB)、三酰甘油(TG)、胆固醇(TC)、HCV病毒载量(HCV-RNA)、门静脉内径宽度(PVW)、脾脏厚度、腹水等临床资料,探讨HCV感染者发生胆囊疾病的危险因素。结果290例HCV感染者胆囊疾病的总发生率为58.28%(169/290),有胆囊疾病组病程、酗酒史、TG、GGT、PVW、脾脏厚度均高于无胆囊疾病组(P<0.05),酗酒,GGT,脾脏厚度是HCV感染者发生胆囊疾病的独立危险因素。结论HCV感染者胆囊疾病的发生率为58.28%,酗酒、脾脏厚度,GGT是HCV感染者发生胆囊疾病的独立危险因素。

Objective To investigate the occurrence of gallbladder disease and its related risk factors in patients with hepatitis C virus(HCV).Methods According to the results of color ultrasound report,290 cases of HCV infection were divided into the group with gallbladder disease(169 cases)and the group without gallbladder disease(121 cases).The clinical data disease of course,body mass index(BMI),negative emotion,alcoholism history,total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyl transpeptidase(GGT),serum albumin(ALB),triglyceride(TG),cholesterol(TC),HCV viral load(HCV-RNA),portal vein width(PVW),thickness of spleen and ascites were analyzed.The risk factors of gallbladder disease in HCV infected patients were explored.Results The total incidence of gallbladder disease in 290 cases of HCV infection was 58.28%(169/290).The disease course,alcoholism history,TG,GGT,PVW and thickness of spleen of the group with gallbladder disease were higher than those without gallbladder disease(P<0.05).Logistic regression analysis showed that alcoholism,GGT and spleen thickness were independent risk factors for gallbladder disease in HCV infected patients.Conclusion The incidence of gallbladder disease in patients with HCV infection was 58.28%.Alcoholism,spleen thickness and GGT were independent risk factors for gallbladder disease in patients with HCV infection.