调强放疗对比三维适形放疗治疗非小细胞肺癌的疗效及对血清CEA、CYFRA21-1的影响

Therapeutic Effect of Intensity-modulated Radiotherapy and Three-dimensional Conformal Radiotherapy for Non-small Cell Lung Cancer and its Effect on Serum CEA and CYFRA21-1

目的探讨对非小细胞肺癌进行调强放疗(IMRT)与三维适形放疗(3D-CRT)的临床效果,并观察血清CEA、CYFRA21-1的变化。方法将77例非小细胞肺癌患者按随机数字法分为2组,38例行IMRT,设为甲组;39组行3D-CRT设为乙组。观察2组临床疗效及并发症情况;并对比治疗前后2组血清癌胚抗原(CEA)、细胞角蛋白19片段抗原21-1(CYFRA21-1)水平变化。结果2组患者临床有效率无明显差异(P>0.05),但甲组放疗后并发症发生率相比乙组明显更低(P<0.05),且血清CEA、CYFRA21-1水平明显低于乙组(P<0.05)。结论IMRT、3D-CRT在非小细胞肺癌治疗中均有良好疗效,且IMRT可有效降低非小细胞肺癌患者放疗后并发症发生率、降低血清CEA及CYFRA21-1水平,值得推广。

Objective To analyze the clinical effects of IMRT and 3D-CRT in non-small cell lung cancer,and to observe the effects of serum CEA and CYFRA21-1.Methods 77 patients with non-small cell lung cancer were enrolled in the study.According to the random number method,they were divided into 2 groups.38 patients underwent IMRT and were assigned to group A and 39 groups.3D-CRT was set as group B.The clinical efficacy and complications of the 2 groups were observed.The levels of serum carcinoembryonic antigen(CEA)and cytokeratin 19 fragment antigen 21-1(CYFRA21-1)were compared before and after treatment.Results There was no significant difference in clinical efficacy between the 2 groups(P>0.05).However,the incidence of complications after radiotherapy was significantly lower in group A than in group B(P<0.05),and serum CEA and CYFRA21-1 levels were significantly lower in group B(P<0.05).Conclusion IMRT and 3D-CRT have good curative effect in the treatment of non-small cell lung cancer,and IMRT can effectively reduce the incidence of postoperative complications of non-small cell lung cancer and reduce the levels of serum CEA and CYFRA21-1,which is worthy of promotion.