小胶质细胞活化抑制与中枢炎症反应关系的研究进展

Research progress in the relations between inhibition mechanisms of microglia activiation and neuroinflammation

近年来,小胶质细胞活化成为中枢神经系统疾病的研究热点,其活化导致的中枢神经系统炎症反应对帕金森病、阿尔茨海默病、脊髓损伤及脑损伤等许多神经系统疾病的发生、发展都有重要的影响。随着局部微环境的改变,小胶质细胞的表型及功能会发生不同的变化,从而产生促进或抑制炎症的效果,对疾病产生相应的影响。抑制小胶质细胞的活化从而改善中枢神经系统炎症反应是治疗上述多种疾病的重要研究方向。

In recent years,it has been found that the inflammation of central nervous system caused by microglia activation has an important impact on the occurrence and development of many nervous system diseases,such as Parkinson’s disease,Alzheimer’s disease,spinal cord injury and brain injury.With the change of local microenvironment,the phenotype and function of microglia will change differently,which can promote or inhibit inflammation and have corresponding effects on diseases.Inhibiting the activation of microglia and improving the inflammatory response of central nervous system is an important research direction in the treatment of these diseases.