谷红注射液治疗稳定性冠心病患者临床观察

Clinical Observation of Guhong Injection in Treatment of Stable Coronary Heart Disease

目的探讨谷红注射液治疗稳定性冠心病患者的的临床疗效。目的选择2017年1月-2018年1月在本院就诊的稳定性冠心病患者72例,按照治疗方案不同,分为对照组和谷红治疗组各36例,通过冠状动脉造影确定患者病变血管支数,采用Gensini积分系统评价患者冠状动脉狭窄程度。两组患者于治疗前后,分别检测血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、超敏C反应蛋白水平。以电话随访方式统计主要心血管事件发生次数,每位患者随访至2019年2月或直至发生MACE。结果两组患者在性别、年龄、病变血管支数、最大狭窄程度、Gensini积分方面差异无统计学意义。两组患者治疗前血脂、超敏C反应蛋白水平差异无统计学意义,治疗后各项指标较治疗前均有明显改善,差异有统计学意义(P<0.05);谷红治疗组血脂、超敏C反应蛋白水平较对照组治疗后降低更为明显,差异有统计学意义(P<0.05)。对照组患者在被随访期间发生再发心肌梗死、心力衰竭的MACE情况均高于治疗组患者(P<0.05),但顽固性心绞痛、心源性死亡事件,两组间差异无统计学意义。结论常规治疗的基础上加用谷红注射液可以提高对稳定性冠心病的疗效。

Objective To explore the clinical efficacy of Guhong Injection in the treatment of stable coronary heart disease.Methods From January 2017 to January 2018,72 patients with stable coronary heart disease were divided into control group and Guhong Injection treatment group according to different treatment schemes.The number of lesion vessels was determined by coronary angiography,and the degree of coronary artery stenosis was evaluated by Gensini integral system.The levels of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)and hypersensitive C-reactive protein(hs-CRP)were measured before and after treatment in both groups.The number of major cardiovascular events was counted by telephone follow-up.Each patient was followed up until February 2019 or until MACE.Results There were no significant differences in gender,age,number of vessel branches,maximum stenosis degree or Gensini score between the two groups.There was no significant difference in serum lipid or hypersensitive C-reactive protein levels between the two groups before treatment.After treatment,the indexes were significantly improved compared with those before treatment(P<0.05),and the levels of serum lipid and hypersensitive C-reactive protein in the Guhong Injection treatment group were significantly lower than those in the control group(P<0.05).During the follow-up period,the incidence of recurrent myocardial infarction and heart failure in the control group was higher than that in the treatment group(P<0.05),but there was no significant difference in refractory angina pectoris and cardiogenic death between the two groups.Conclusion The effect of Guhong Injection on stable coronary heart disease can be improved on the basis of routine treatment.