星点设计-效应面法优选青钱柳滴丸的成型工艺

Optimization of Molding Technology for Qingqianliu Dropping Pills by Central Composite Design-Response Surface Method

目的优选青钱柳滴丸的成型工艺。方法以基质(聚乙二醇4000)与药物的比例、料液温度、滴距为考察因素,以外观质量和溶散时限为考察指标,采用星点设计-效应面法优选青钱柳滴丸的最佳成型工艺。结果青钱柳滴丸最佳成型工艺为:基质(聚乙二醇4000)与药物的比例2. 7:1,料液温度84℃,滴距4 cm。结论青钱柳滴丸的成型工艺合理可行,稳定可靠。

Objective To optimize the molding technology of Qingqianliu Dropping Pills. Methods The ratio of matrix( polyethylene glycol 4000) to extract from Qingqianliu Dropping Pills,the dropping temperature and the dropping distance were taken as the investigation factors,while the quality of appearance and dissolution time were taken as investigation indexes. The central composite design-response surface method was used to optimize the molding process. Results The optimized conditions were as follows: the ratio of matrix( polyethylene glycol 4000) to extract was 2. 7: 1,the dropping temperature was 84 ℃,and the dropping distance was 4 cm. Conclusion The molding technology of Qingqianliu Dropping Pills is reasonable and feasible,stable and reliable.