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西红花苷生物合成途径研究进展 被引量:1

Research Progress on Biosynthetic Pathway of Crocin
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摘要 西红花苷是一种由藏花酸和葡萄糖或龙胆二糖形成的类胡萝卜素类化合物,具有抗动脉粥样硬化、抗高血压、降血脂、抗氧化、抗抑郁、抗癌、抗炎等药理活性。然而,西红花苷类成分在植物界分布较窄,含量较低,且提取工艺复杂,导致其供不应求。随着基因组和转录组测序技术的发展,参与西红花苷合成途径的相关酶基因逐渐被克隆和鉴定。对西红花苷生物合成路径以及该通路相关酶基因的研究现状进行综述,以期为利用代谢工程生产或提高西红花苷类物质提供理论基础,从而扩大西红花苷的开发利用。 Crocin is a kind of carotenoid compound containing crocetin and glucose or gentiane disaccharide,which possesses extensive anti-atherosclerosis,anti-hypertension,anti-hyperlipidemia,anti-oxidation,anti-depression,anticancer,anti-inflammatory,and other pharmacological activities.However,the narrow distribution and low content of crocin in plants,as well as the complicated extraction process have led to the shortage of crocin.With the development of genome and transcriptome sequencing,the related enzyme genes involved in the crocin biosynthesis pathway were cloned and identified.Herein,the research status of crocin biosynthesis pathway and the related enzyme genes were reviewed,hoping to provide theoretical basis for using metabolic engineering to produce or improve crocin substances,and expand the exploitation and utilization of crocin.
作者 叶军 张翔 朱睿睿 赵玉成 谢国勇 秦民坚 Ye Jun;Zhang Xiang;Zhu Ruirui;Zhao Yucheng;Xie Guoyong;Qin Minjian(School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China)
出处 《中国野生植物资源》 CSCD 2020年第5期38-44,48,共8页 Chinese Wild Plant Resources
基金 国家自然科学基金资助项目(81503220) 江苏省自然科学基金资助项目(BK20150706)。
关键词 西红花苷 生物合成 类胡萝卜素裂解双加氧酶 醛脱氢酶 UDP-糖基转移酶 Crocin Biosynthetic pathway Carotenoid cleavage dioxygenase Aldehyde dehydrogenase UDP-glucosyltransferase
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