清肺通腑方对急性加重慢性支气管炎型慢性阻塞性肺疾病临床研究

Clinical Study on Qingfei Tongfu Prescription for Acute Exacerbation of Chronic Obstructive Pulmonary Disease of Chronic Bronchitis Type

目的:观察清肺通腑方对急性加重慢性支气管炎型慢性阻塞性肺疾病(COPD)的疗效。方法:将90例急性加重慢性支气管炎型COPD患者,随机分为A组、B组和C组,每组30例,A组采用常规治疗,B组采用常规治疗联合阿奇霉素,C组采用常规治疗加阿奇霉素联合清肺通腑方。比较3组的临床疗效以及治疗后肺功能指标。结果:经过治疗后,C组临床疗效最佳,总有效率为93.33%;其次是B组,总有效率为80.00%;临床疗效最差为A组,3组临床疗效比较,差异有统计学意义(P<0.01)。经治疗,C组用力肺活量(FVC)、1 s用力呼气容积(FEV1)及1 s率(FEV1%)均优于B组和A组,差异有统计学意义(P<0.05)。B组FVC、FEV1及FEV1%均优于A组(P<0.05)。结论:在常规治疗的基础上采用清肺通腑方联合阿奇霉素治疗急性加重慢性支气管炎型COPD老年患者的临床效果显著,常规治疗联合阿奇霉素的疗效次之,常规方法疗效最次,但均能有效改善患者肺功能。

Objective:To observe the curative effect of Qingfei Tongfu prescription for acute exacerbation of chronic obstructive pulmonary disease(COPD)of chronic bronchitis type.Methods:A total of 90 patients with acute exacerbation of COPD of chronic bronchitis type were randomly divided into Group A,Group B and Group C,30 patients in each group(P<0.05).Group A received conventional treatment;Group B received conventional treatment combined with azithromycin,and Group C received conventional treatment combined with azithromycin as well as Qingfei Tongfu prescription.The three groups were compared in terms of clinical effect and pulmonary function after treatment.Results:After treatment,Group C had the best clinical effect,with the total effective rate of 93.33%,followed by Group B(80.00%),and Group A the worst,the difference being significant(P<0.01).After treatment,Group C had better forced vital capacity(FVC),forced expiratory volume in one second(FEV1)and the rate in one second(FEV1%)than Group B and Group A,the difference being significant(P<0.05).The FVC,FEV1 and FEV1%in Group B were better than those in Group A(P<0.05).Conclusion:The therapy of Qingfei Tongfu prescription combined with azithromycin as well as conventional treatment has the most significant therapeutic effect in treating senile patients with acute exacerbation of COPD of chronic bronchitis type,followed by conventional treatment combined with azithromycin,and the conventional treatment the least.