两种用药方案治疗溃疡性结肠炎的临床评价

Clinical Evaluation of Two Medication Regimens in the Treatment of Ulcerative Colitis

目的评价两种用药方案治疗溃疡性结肠炎的临床疗效,为临床医师选择合理用药方案提供参考。方法选则2016年1月至2018年12月辽宁中置盛京老年病医院消化内科收治的溃疡性结肠炎患者88例为研究对象,按照随机数字分组法将其分为对照组和试验组(每组44例),对照组采用美沙拉嗪联合复方谷氨酰胺肠溶胶囊治疗,试验组采用双歧杆菌三联活菌胶囊联合美沙拉嗪,对患者资料进行回顾性分析,比较两组的临床疗效、症状消失时间和炎性因子水平。结果试验组临床总有效率(93.18%)与对照组(88.63%)相比稍高,但差异不存在统计学意义,P>0.05;试验组患者脓血便、腹痛、腹泻消失时间均较对照组早,P<0.05;试验组治疗前1周白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)与对照组相比存在差异,但P>0.05,治疗后4周两组上述指标降低,试验组较对照组低,P<0.05。结论在溃疡性结肠炎患者治疗中,美沙拉嗪联合复方谷氨酸酰胺肠溶胶囊或双歧杆菌三联活菌胶囊疗效理想,但双歧杆菌三联活菌胶囊炎性因子抑制作用较强,患者症状恢复快,值得借鉴。

Objective To evaluate the clinical efficacy of two medication regimens in the treatment of ulcerative colitis,and to provide references for clinicians to choose rational medication regimens.Methods 88 cases with ulcerative colitis admitted to Department of Gastroenterology,Zhongzhi-Shengjing Geriatric Hospitalduring from January 2016 to December 2018 were selected as the study subjects.They were divided into control group and experimental group according to random number grouping method(44 cases in each group).The control group was treated with mesalazine combined with compound glutamine enteric-coated capsules,and the experimental group was treated with Bifidobacterium triple viable capsules combined with methylsalazine.The data of patients were retrospectively analyzed,and the clinical efficacy,the disappearance time of symptoms and the level of inflammatory factors were compared between the two groups.Results The total clinical effective rate of the experimental group(93.18%)was slightly higher than that of the control group(88.63%),but the difference was not statistically significant(P>0.05);the disappearance time of pus,bloody stool,abdominal pain and diarrhea of the experimental group was earlier than that of the control group(P<0.05);there were differences in interleukin-6(IL-6)and hypersensitive C-reactive protein(hs-CRP)between the experimental group and the control group one week before treatment,but P>0.05,treatment.Four weeks after treatment,the above indexes in the two groups were lower than those in the control group(P<0.05).Conclusion Mesalazine combined with compound glutamic acid entericcoated capsule or Bifidobacterium triple viable capsule is effective in the treatment of ulcerative colitis,but Bifidobacterium triple viable capsule has strong inhibitory effect on inflammatory factors and rapid recovery of symptoms.