高通量血液透析治疗终末期肾功能衰竭的临床疗效观察

High Flux Hemodialysis in the Treatment of End-stage Renal Failure

目的对终末期肾功能衰竭患者实施高通量血液透析治疗的临床疗效进行分析观察。方法本次采取随机数字分组法,将我院在2017年2月至2018年2月收治的84例终末期肾功能衰竭患者分成两组;其中,对照组42例采取常规血液透析方法医治,观察组42例采取高通量血液透析方法医治,进一步比较两组医治效果。结果①在治疗总有效率方面,观察组为95.24%,与对照组的73.81%对比显著更高,两组数据差异具备统计学意义(P<0.05)。②在血红蛋白、血清白蛋白、血清磷、甲状旁腺激素以及血清β2-微球蛋白五项血液生化指标方面,治疗前两组均无明显差异(P>0.05);治疗后,观察组均明显优于对照组,两组数据之间存在明显统计学差异(P<0.05)。③观察组症状改善时间及指标纠正时间均明显短于对照组,两组数据差异具备统计学意义(P<0.05)。④观察组并发症总发生率为4.76%,与对照组的30.95%比较显著更低,两组数据之间存在明显统计学差异(P<0.05)。结论针对终末期肾功能衰竭患者,采取高通量血液透析治疗具备显著疗效,能够使患者的肾功能得到有效改善,并降低并发症发生率,进一步改善患者生存质量;因此,值得在临床医治工作中采纳及应用。

Objective To analyze and observe the clinical effect of high flux hemodialysis in patients with end-stage renal failure.Method In this study,84 patients with end-stage renal failure in our hospital were divided into two groups by random number grouping method.42 patients in the control group were treated by routine hemodialysis,and 42 patients in the observation group were treated by high-flux hemodialysis.Result(1)In terms of the total effective rate of treatment,the observation group was 95.24%,which was significantly higher than the control group’s 73.81%.The difference between the two groups was statistically significant(P<0.05).(2)There was no significant difference in five blood biochemical indexes of hemoglobin,serum albumin,serum phosphorus,parathyroid hormone and serum beta-2-microglobulin between the two groups before treatment(P>0.05);after treatment,the observation group was significantly better than the control group,and there was significant statistical difference between the two groups(P<0.05).(3)The improvement time of symptoms and the correction time of indicators in the observation group were significantly shorter than those in the control group,and the difference between the two groups was statistically significant(P<0.05).(4)The total incidence of complications in the observation group was 4.76%,which was significantly lower than that in the control group(30.95%).There was a significant statistical difference between the two groups(P<0.05).Conclusion For patients with end-stage renal failure,high-throughput hemodialysis has a significant effect,which can effectively improve the renal function of patients,reduce the incidence of complications,and further improve the quality of life of patients;therefore,it is worthy of adoption and application in clinical treatment.