艾普拉唑联合铋剂在幽门螺杆菌感染性胃炎中的应用

APPLICATION OF ILAPRAZOLE COMBINED WITH BISMUTH IN HP INFECTIOUS GASTRITIS

目的探讨HP感染性慢性胃炎的治疗方法。方法选取100例HP感染性慢性胃炎患者,将其随机分为两组,各50例。对照组采取艾普拉唑联合铋剂标准四联进行治疗,观察组采取序贯方案治疗。观察两组临床有效率、HP根除率及不良反应发生率。结果观察组总有效率及HP根除率均为96%,高于对照组的78%、80%(χ^2=5.66,4.64;P<0.05);两组不良反应发生率对比无明显差异(P>0.05)。结论序贯方案是治疗HP感染性慢性胃炎的有效方法,且安全性好。

Objective To explore the treatment of HP infectious chronic gastritis.Methods One hundred patients with chronic HP gastritis were selected and randomly divided into two groups,50 cases each.The control group was treated with ilaprazole combined with bismuth standard quadruple,and the observation group was treated with sequential regimen.The clinical effectiveness,HP eradication rate,and adverse reaction rate of the two groups were observed.Results The total effective rate and HP eradication rate of the observation group were 96%,which were higher than the 78%and 80%of the control group(χ^2=5.66,4.64;P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The sequential scheme is an effective method for the treatment of HP-infected chronic gastritis with great safety.