甘精胰岛素联合瑞格列奈治疗Ⅱ型糖尿病的有效性和安全性分析

ANALYSIS OF THE EFFICACY AND SAFETY OF INSULIN GLARGINE COMBINED WITH REGLINIDE IN THE TREATMENT OF TYPEⅡDIABETES

目的探讨Ⅱ型糖尿病的治疗方法。方法选取70例Ⅱ型糖尿病患者,将其随机分为联合组与对照组,各35例。联合组采取甘精胰岛素+瑞格列奈治疗,对照组采取阿卡波糖治疗。比较两组的有效性和安全性。结果联合组总有效率为97.14%,高于对照组的77.14%(χ^2=4.59,P=0.032);空腹血糖、餐后2h血糖及糖化血红蛋白改善程度大于对照组(t=8.03~10.02,P<0.01);不良反应发生率低于对照组(χ^2=3.88,P=0.049)。结论甘精胰岛素联合瑞格列奈治疗Ⅱ型糖尿病,具有较好的有效性和安全性。

Objective To explore the treatment of typeⅡdiabetes.Methods Seventy patients with typeⅡdiabetes were selected and randomly divided into a combination group and a control group,35 cases each.The combination group was treated with Insulin glargine plus Reglinide,and the control group was treated with acarbose.The effectiveness and safety of the two groups were compared.Results The total effective rate in the combined group was 97.14%,higher than the 77.14%in the the control group(χ^2=4.59,P=0.032).Fasting blood glucose,2h postprandial blood glucose,and glycated hemoglobin improved more than those of the control group(t=8.03-10.02,P<0.01).The incidence of adverse reactions was lower than that of the control group(χ^2=3.88,P=0.049).Conclusion Insulin glargine combined with Reglinide has good efficacy and safety in the treatment of type 2 diabetes.