脾多肽注射液辅助治疗对结直肠癌患者T淋巴细胞、免疫因子的影响

Effects of Spleen Polypeptide Injection Adjuvant Therapy on T Lymphocyte and Immunologic Factors in Patients with Colorectal Carcinoma

目的分析脾多肽注射液辅助治疗对结直肠癌患者T淋巴细胞及免疫因子的影响,为结直肠癌患者的临床治疗提供参考。方法选取2016年3月—2018年4月在南京医科大学第一附属医院诊断且符合纳入标准的88例伴有不可切除肝转移的晚期结直肠癌患者为研究对象,采用随机数字表法将其分为观察组和对照组,每组各44例,对照组患者行常规化疗,观察组在对照组基础上加用脾多肽注射液治疗,比较2组患者的临床疗效、T淋巴细胞及免疫因子水平。结果观察组患者的临床治疗总有效率明显高于对照组(P<0.05);治疗前,2组患者的T淋巴细胞及免疫因子水平均无显著差异,治疗后,2组患者的CD3^+、CD4^+、CD4^+/CD8^+及自然杀伤细胞水平均明显高于治疗前(P<0.05),且观察组明显高于对照组(P<0.05),2组患者的CD8^+、可溶性白细胞介素-2受体及白细胞介素-8水平均明显低于治疗前(P<0.05),且观察组明显低于对照组(P<0.05)。结论脾多肽注射液辅助治疗可提高结直肠癌患者临床疗效,改善患者T淋巴细胞及免疫因子水平。

OBJECTIVE To analyze the effects of spleen polypeptide injection adjuvant therapy on T lymphocyte and immunologic factors in patients with colorectal carcinoma,to provide reference for clinical treatment of patients with colorectal carcinoma.METHODS A total of 88 advanced colorectal carcinoma patients with unresectable liver metastasis who were dignoised and inclusion criteria in the First Affiliated Hospital of Nanjing Medical University were selected from March 2016 to April 2018,and they were divided into observation group(n=44)and control group(n=44)according to the random number table method.Patients in the control group were treated with conventional chemotherapy,and the observation group was treated with spleen polypeptide injection on the basis of the control group.The clinical effect,the levels of T lymphocyte and immunologic factors were compared between the two groups.RESULTS The total effective rate of clinical treatment in observation group was obviously higher than that of control group(P<0.05).Before treatment,there were no significantly differences in the level of T lymphocyte and immunologic factors between the two groups.After treatment,the level of CD3^+,CD4^+,CD4^+/CD8^+and natural killer in the two groups were obviously higher than those of before treatment(P<0.05),and the observation group was obviously higher than the control group(P<0.05).The level of CD8^+,soluble interleukin-2 receptor and interleukin-8 in the two groups were obviously lower than those of before treatment(P<0.05),and the observation group was obviously lower than the control group(P<0.05).CONCLUSION The spleen polypeptide injection adjuvant therapy can improve the clinical effects of patients with colorectal carcinoma,and improve the levels of T lymphocyte and immunologic factors.