摘要
早幼粒细胞白血病蛋白(promyelocytic leukemia protein,PML)参与调节细胞凋亡、衰老、DNA修复等多种生物学过程。同时,PML蛋白作为一种肿瘤抑制因子,在多种肿瘤中的表达均有明显下调的趋势,表明其与肿瘤的形成密切相关。虽然已有较多文献对PML蛋白参与恶性肿瘤发生发展的分子机制进行了深入研究,但是并未被系统地归纳总结。本文深入剖析当前研究现状,从PML蛋白调控细胞凋亡、抑制细胞生长、抑制癌细胞转化和迁移、促进细胞衰老,以及抑制血管生成等方面,全面总结了PML蛋白在肿瘤发生发展过程中的调节机制,以期为PML蛋白的全面认知及为相关恶性肿瘤的预防和治疗提供新思路。
Promyelocytic leukemia protein(PML)is a tumor suppressor that involved in the regulation of various biological processes such as cell apoptosis,cell senescence,and DNA repair.In several type of tumors,PML protein was found to be significantly down-regulated,indicating that it plays an important role on preventing tumor formation.Although there are many literatures focusing on the molecular mechanism of PML protein in regulating the development of malignant tumors,but it has not been systematically summarized.In this review,the current research status,and comprehensively summarize the effect of PML protein on tumorigenesis including the regulation of cell apoptosis,cell proliferation,cell migration and metastasis,cellular senescence,and angiogenesis was analyzed.In order to provide a new idea for treatment of related malignant tumors.
作者
苏力德
邵一鸣
郝睿
王茜茜
部娜
马丽亚
那仁满都拉
SU Lide;SHAO Yiming;HAO Rui;WANG Qianqian;BU Na;MA Liya;NARANMANDURA Hua(College of Pharmaceutical Sciences,Inner Mongolia Medical University,Hohhot 010000,China;Zhejiang University,School of Medicine,School of Public Health,Hangzhou 310000,China;Zhejiang University,School of Medicine,Department of Pharmacology,Hangzhou 310000,China;Department of Pharmacy,Women’s Hospital,School of Medicine,Zhejiang University,Hangzhou 310000,China;Department of Hematology,the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310000,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2020年第7期886-890,共5页
Chinese Journal of Modern Applied Pharmacy
基金
国家自然科学基金项目(81673521,81872942,81603125,81600139)。
关键词
早幼粒细胞白血病蛋白
肿瘤细胞
细胞凋亡
细胞衰老
调节血管生成
研究进展
promyelocytic leukemia protein(PML)
tumor cells
cell apoptosis
cellular senescence
regulation of angiogenesis
research progress
