肝脏剪切波弹性成像在评价慢性乙肝患者恩替卡韦治疗效果中的应用价值

Application value of liver shear wave elastography in evaluating efficacy of entecavirin chronic hepatitis B patients

目的研究肝脏剪切波弹性成像在评价慢性乙肝患者恩替卡韦治疗效果中的应用价值。方法随机选取2018年1月~2019年1月来本院接受治疗的124例慢性乙肝患者作为研究对象,按照肝纤维化程度分为A组(S0、S1)、B组(S2、S3)以及C组(S4),所有患者均给予恩替卡韦治疗,分别于治疗前以及治疗6个月后进行肝脏剪切波弹性成像检查,比较患者治疗前后肝硬度值以及肝功能指标变化。结果治疗前,肝功能各指标水平[丙氨酸氨基转移酶(ALT)、总胆红素(TBiL)、碱性磷酸酶(ALP)和天冬氨酸氨基转移酶(AST)]、肝硬度值均为A组<B组<C组;治疗后,三组患者肝功能水平、肝硬度值均明显降低(P<0.05),肝硬度值与肝功能指标治疗前后的变化趋势相同。结论肝脏剪切波弹性成像可作为评估慢性乙肝患者恩替卡韦治疗效果的可靠指标,值得临床推广应用。

Objective To investigate the application value of liver shear wave elastography in evaluating efficacy of entecavir in chronic hepatitis B patients.Methods One hundred and twenty-four patients with chronic hepatitis B received treatment at our hospital from January 2018 to January 2019 were selected at random as subjects and divided into group A(S0,S1),group B(S2,S3)and group C(S4)by liver fibrosis degree.All patients were administered with entecavir for treatment.The liver shear wave elastography would be performed before treatment and in 6 months after treatment respectively to compare the liver hardenability values and changes of hepatic function indexes before and after treatment.Results Before treatment,various hepatic function levels[alanine aminotransferase(ALT),total bilirubin(TBiL),alkaline phosphatase(ALP)and aspartate aminotransferase(AST)]and liver hardenability were all ranked as group A<group B<group C;after treatment,liver function levels and liver hardenability of patients in three groups were all significantly decreased(P<0.05).The change trends of liver hardenability and liver function indexes before and after treatment were identical.Conclusion Liver shear wave elastography could be used as reliable index to evaluate the efficacy of entecavir for chronic hepatitis B patients,worthy of clinical application.