重组人脑利钠肽对AMI心力衰竭患者循环内分泌的影响分析

Effects of recombinant human brain natriuretic peptide on circular endocrine in patients with heart failure caused by AMI

目的分析重组人脑利钠肽对AMI心力衰竭患者循环内分泌的影响。方法随机选取2017年8月~2019年8月我院AMI心力衰竭患者90例,随机分为常规基础性治疗组(n=45)和常规基础性治疗联合重组人脑利钠肽治疗组(重组人脑利钠肽组,n=45),统计分析两组患者的生命体征、血清PRA、ALD、ATⅡ、NT-ProBNP、hs-CRP水平、LVDd、LVEF、心力衰竭缓解情况。结果重组人脑利钠肽组患者治疗后较治疗前的心率、中心静脉压、收缩压降低幅度、24h尿量增加幅度均显著高于常规基础性治疗组(P<0.05)。重组人脑利钠肽组患者治疗后较治疗前的血清PRA、ALD、ATⅡ水平降低幅度均显著高于常规基础性治疗组,差异有统计学意义(P<0.05)。重组人脑利钠肽组患者治疗后较治疗前的血清NTProBNP、hs-CRP水平、LVDd降低幅度、LVEF升高幅度均显著高于常规基础性治疗组,差异有统计学意义(P<0.05)。重组人脑利钠肽组患者的心力衰竭缓解率88.9%(40/45)显著高于常规基础性治疗组64.4%(29/45),差异有统计学意义(P<0.05)。结论重组人脑利钠肽能够有效改善AMI心力衰竭患者循环内分泌。

Objective To analyze the effect of recombinant human brain natriuretic peptide(rhBNP)on circular endocrine in patients with heart failure caused by acute myocardial infarction(AMI).Methods 90 heart failure patients caused by AMI treated in our hospital from August 2017 to August 2019 were randomly selected and divided into a conventional group and rhBNP group,with 45 cases in each group.The conventional group received conventional basic treatment,and the rhBNP group received conventional basic treatment combined with rhBNP treatment.The vital signs,serum plasma renin assay(PRA),aldosterone(ALD),angiotensin 2(ATⅡ),N-terminal probrain natriuretic peptide(NT-ProBNP),hypersensitive C-reactive protein(hs-CRP)levels,left ventricular end diastolic dimension(LVDd),left ventricular ejection fractions(LVEF),and remission of heart failure were statistically analyzed between the two groups.Results After treatment,the decrease degree of heart rate,central venous pressure and systolic blood pressure and the increase degree of urine volume at 24h of the rhBNP group were significantly higher than those of the conventional group(P<0.05).The decrease degree of serum PRA,ALD,and ATⅡlevel of the rhBNP group was significantly higher than that of the conventional group after treatment,and the difference was statistically significant(P<0.05).The decrease degree of serum NT-ProBNP,hs-CRP level and LVDd and the increase degree of LVEF of the rhBNP group were significantly higher than those of the conventional group,and the differences were statistically significant(P<0.05).The heart failure remission rate of the rhBNP group was 88.9%(40/45),which was significantly higher than 64.4%(29/45)of the conventional group,and the difference was statistically significant(P<0.05).Conclusion The rhBNP can effectively improve circular endocrine in patients with heart failure caused by AMI.