紫杉醇加顺铂治疗晚期老年非小细胞癌的疗效

Paclitaxel Plus Cisplatin in the Treatment of Advanced Elderly Non-small Cell Carcinoma

目的研究紫杉醇加顺铂治疗晚期老年非小细胞癌临床疗效。方法选取2017年3月~2018年3月在我院治疗的94例晚期老年非小细胞癌患者为研究对象,采用随机数字表法分为对照组和观察组,各47例。对照组采用顺铂治疗,观察组在对照组基础上加用紫杉醇,比较两组临床治疗总有效率、免疫功能指标(CD4、CD8、CD4/CD8)、生存率(10个月、20个月)以及毒副反应(白细胞减少、消化道反应、肝肾功能异常、血小板降低)发生情况。结果观察组治疗总有效率为82.97%,高于对照组的72.34%(P<0.05);治疗后两组免疫功能指标CD4、CD8、CD4/CD8均高于治疗前,且观察组高于对照组(P<0.05);观察组生存率高于对照组(P<0.05);观察组毒副反应发生率为17.02%,与对照组的19.14%比较,差异无统计学意义(P>0.05)。结论紫杉醇加顺铂治疗晚期老年非小细胞癌有效率高,有助于提高患者免疫功能,促进治疗耐受性,增加患者的生存时间,且毒副反应少,具有重要的临床应用价值。

Objective To study the clinical efficacy of paclitaxel plus cisplatin in the treatment of advanced elderly non-small cell carcinoma.Methods 94 patients with advanced non-small cell carcinoma who were treated in our hospital from March 2017 to March 2018 were selected as the research object. They were divided into a control group and an observation group with a random number table method, each with 47 cases. The control group was treated with cisplatin. The observation group was added paclitaxel on the basis of the control group. The total clinical efficacy, immune function indexes(CD4, CD8, CD4/CD8) and survival rate(10 months, 20 months) of the two groups were compared and the occurrence of side effects(leukopenia, gastrointestinal reactions, liver and kidney dysfunction, platelet reduction).Results The total effective rate of treatment in the observation group was 82.97%, higher than 72.34% in the control group(P <0.05);after treatment, the immune function indexes CD4, CD8, CD4/CD8 of both groups were higher than before treatment, and the observation group was higher than the control group(P<0.05);the survival rate of the observation group was higher than the control group(P<0.05);the incidence of side effects in the observation group was 17.02%, and compared with 19.14% of the control group, the difference was not statistically significant(P >0.05).Conclusion Paclitaxel plus cisplatin is highly effective in the treatment of advanced non-small cell carcinoma of the elderly. It can help improve the immune function of patients, promote treatment tolerance, increase the survival time of patients, and have fewer toxic and side reactions.