药物性胆管损伤研究进展

Study Progresses of Drug-Induced Bile Duct Injury

目的探讨药物性胆管损伤的研究现状,为临床安全用药提供依据。方法查阅国内外文献,总结药物性胆管损伤的临床表现、损伤类型及治疗等的最新研究进展。结果常见药物性胆管损伤包括胆管缺失、胆囊损伤、胆汁淤积、继发性硬化性胆管炎、胆管癌等。目前尚缺乏有效的治疗手段,且其损伤机制仍不明确。结论临床应重视药物性胆管损伤的预防和治疗。

Objective To investigate the research status of drug-induced bile duct injury and provide reference for safe medication.Methods The domestic and foreign articles were reviewed,and the latest research progresses of drug-induced bile duct injury were summarized on the aspects of type,mechanism and treatment.Results Bile duct loss,cholestasis,secondary sclerosing cholangitis,gallbladder injury and cholangiocarcinoma were the common types of drug-induced bile duct injury.There is a lack of effective treatments and its pathogenesis is still unclear.Conclusion We should pay more attention to the prevention and treatment of drug-induced bile duct injury in the clinic.