摘要
目的探讨新型抗癫痫药物加巴喷丁及普瑞巴林治疗慢性瘙痒的作用机制、疗效及安全性。方法统计已公开发表的关于加巴喷丁和普瑞巴林治疗慢性瘙痒症状的原始文献,分析其有效性及安全性。结果与结论加巴喷丁及普瑞巴林作为新型抗癫痫药物,对多种慢性瘙痒均有不同程度的缓解作用,尤其对肾性瘙痒、神经病理性瘙痒及烧伤后瘙痒疗效显著,但作用机制尚不明确,常见不良反应为头晕、嗜睡等,多可逐渐耐受或通过减量、停药能明显缓解,建议临床从低剂量开始逐步加量使用。
Objective To explore the mechanism,efficacy and safety of a new class of antiepileptic drugs for chronic pruritus.Methods The original articles published to date evaluating the use of gabapentin and pregabalin as antipruritic agents were studied,and their effectiveness and safety were analyzed.Results and Conlusion Gabapentin and pregabalin,as a new type of antiepileptic drug,can significantly reduce the nervous system excitability and relieve various chronic pruritus to different degrees,especially for renal itching,neuropathic itching and pruritus after burn.However,the mechanism of action is not yet clear.The common adverse reactions are dizziness,drowsiness,etc.,which can be gradually tolerated or can be significantly relieved by reducing the amount or stopping the drug.It is recommended to gradually increase the amount of clinical use from low dose.
作者
张文
蔡涛
ZHANG Wen;CAI Tao(The First Affiliated Hospital of Chongqing Medical University,Chongqing,China 400016)
出处
《中国药业》
CAS
2020年第10期153-156,I0001-I0004,共8页
China Pharmaceuticals
基金
重庆市自然科学基金[cstc2018jcyjAX0558]。
