幽门螺杆菌感染与代谢综合征参数变化的相关性研究

Correlation between Helicobacter pylori infection and changes in parameters of metabolic syndrome

目的探讨幽门螺杆菌(Helicobacter pylori,H.pylori)感染对代谢综合征(metabolic syndrome,MS)参数变化的影响。方法选取2016年1月1日至2018年8月31日至徐州医科大学附属医院体检人群,检查项目包括进行14C呼气试验、血脂、肝肾功能、空腹血糖(fasting blood glucose,FBG)、血压和体质指数(body mass index,BMI)等检测,一般资料及病史完整的体检者1 700例,并选取连续两年入院体检并在第一年诊断H.pylori感染合并MS体检者456例,根据检查结果分为H.pylori根除组(n=158),H.pylori未根除但感染程度减轻组(n=224)和感染程度未减轻组(n=74)。分析H.pylori感染、年龄、性别与MS的相关性。比较各组体检者一年前后BMI、舒张压(diastolic blood pressure,DBP)、收缩压(systolic blood pressure,SBP)、FBG、高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)、甘油三酯(triglyceride,TG)的变化,分析H.pylori感染对MS参数变化的影响。结果对合并MS体检者进行多因素Logistic逐步回归分析,结果显示H.pylori感染、年龄、性别是MS的独立危险因素。H.pylori根除组及H.pylori感染程度减轻组BMI、SBP、DBP一年后较一年前无明显改变,差异无统计学意义(P>0.05),FBG、TG一年后较一年前明显降低,差异有统计学意义(P<0.05)。HDL-C则较一年前升高,差异有统计学意义(P<0.05)。H.pylori感染程度未减轻组BMI、SBP、DBP、FBG、TG、HDL-C一年前较一年后未见明显改变(P>0.05)。性别、年龄对H.pylori根除体检者MS前后相关参数变化无明显影响(P>0.05)。结论 H.pylori感染、年龄、性别与MS的发生密切相关;H.pylori的根除或感染程度的减轻与否,可改善机体血糖、血脂等状况。

Objective To study the effect of Helicobacter pylori(H.pylori) infection on changes in parameters of metabolic syndrome(MS).Methods Physical examination population from Jan. 1 st 2016 to Aug. 31 st 2018 in Affiliated Hospital of Xuzhou Medical University were collected, inspection items included 14C breath test, blood lipids, liver and kidney function, fasting blood glucose(FBG), blood pressure and body mass index(BMI) and other tests, general information and medical history of 1 700 patients were complete. And 456 patients who were admitted to the hospital for two consecutive years and diagnosed with H.pylori infection and MS in the first year were chosen. According to the test results, they were divided into H.pylori eradication group(n=158), H.pylori reduced infection group(n=224) and the H.pylori infection not alleviated group(n=74). The correlation of H.pylori infection, age, gender with MS was analyzed. Changes of BMI, diastolic blood pressure(DBP), systolic blood pressure(SBP), FBG, high density lipoprotein-cholesterol(HDL-C), triglyceride(TG) before and after one year were compared, the impact of H.pylori infection on changes in parameters of MS was analyzed. Results Multivariate Logistic stepwise regression analysis of MS showed that H.pylori infection, age and gender were independent risk factors for MS. In H.pylori eradication group and H.pylori reduced infection group, BMI, SBP, DBP were no significant changes after H.pylori eradication one year(P>0.05), FBG, TG were significantly lower after H.pylori eradication one year, the difference was statistically significant(P<0.05), HDL-C was higher after H.pylori eradication one year, the difference was statistically significant(P<0.05). BMI, SBP, DBP, FBG, TG and HDL-C in the physical examination population had no significant changes after H.pylori eradication one year in H.pylori infection not alleviated group(P>0.05). Gender and age had no significant effect on the changes of related parameters before and after MS in H.pylori eradication physical examination population, and the difference was not statistically significant(P>0.05). Conclusion H.pylori infection, age, sex and MS are closely related;the eradication of H.pylori or the reduction of H.pylori infection can affect the blood glucose of patients and improve the blood lipids of patients.