IL-17A在纤维化疾病中的研究进展

Progress on fibrotic diseases via IL-17A

白细胞介素-17A (IL-17A)是一种具有多种生物学功能的细胞因子,参与多种疾病的发病机制,通常情况它被认为在炎症反应中起重要作用,它可以募集炎症细胞至疾病部位,可进一步调节炎症细胞分泌炎症介质等发挥抗炎作用,但近年来研究发现IL-17A在许多纤维化疾病中有促进组织纤维化的作用,本文主要从炎症及纤维化角度分析了IL-17A在相关疾病中的作用,提示以IL-17A为干预靶点有可能使患者受益。

Interleukin-17 A(IL-17 A) is a cytokine with a multi-biological function, which is involved in the pathogenesis of many diseases. Generally, it is considered to play an important role in the inflammatory response. It can recruit inflammatory cells to the site of the disease and further regulate the secretion of inflammatory mediators by inflammatory cells. However, in recent years, IL-17 A has been found to promote tissue fibrosis in many diseases. This article mainly analyzes the role of IL-17 A in related diseases from the perspective of inflammation and fibrosis, suggesting that using IL-17 A as an intervention target may benefit patients.