中性粒细胞胞外诱捕网促进肿瘤局部生长

Neutrophil Extracellular Trapping Nets Promote Local Tumor Growth

中性粒细胞胞外诱捕网(NETs)的释放是新发现的中性粒细胞天然免疫手段。近年来发现NETs不仅执行针对病原体的免疫作用,还参与机体的某些其他病理过程,特别是在肿瘤的生长过程中发挥着重要作用。NETs的成分除了染色质DNA外,还有包括各种组蛋白和胞内颗粒释放蛋白,许多研究证实这些蛋白质与肿瘤的发生、发展有关,如中性粒细胞弹性蛋白酶、基质金属蛋白酶9、白细胞介素8、粒细胞集落刺激因子等可通过降解胰岛素受体底物-1,促进血管内皮生长因子释放,启动NETosis等多种途径促进肿瘤的局部生长。

The release of Neutrophil extracellular traps(NETs) is one of the important means of neutrophil innate immunity. In recent years, it has been found that NETs not only perform immune function against pathogens, but also participate in some pathological processes of the body, especially playing an important role in the growth of tumors. This paper focuses on the latest development of NETs and its products, such as neutrophil elastase, matrix metalloproteinase 9, interleukin 8 and granulocyte colony stimulating factor, on tumor growth.