家庭因素对帕金森病患者预后的影响

Influence of family factors on prognosis of Parkinson's disease patients

目的观察新诊断的帕金森病患者经治疗后1 a的Hoehn-Yahr(修正)分级量表评分,探讨影响帕金森病患者预后的相关因素。方法选择2014-11-01—2016-11-01在乐山市人民医院新诊断的105例帕金森病患者,对其进行大于1 a的随访。详细记录患者的性别、年龄、文化程度、病程、发作类型、脑电图及头颅影像学检查结果、家庭因素。用Excel建立数据库,应用单变量分析和Logistic回归分析判断帕金森病患者预后的影响因素(P<0.05)。结果治疗1 a后患者的缓解率为51%(1 a后患者Hoehn-Yahr评分<3分归入缓解组)。在单因素分析中,缓解组与未缓解组在年龄、病程、脑电图及头颅影像学检查结果、家庭因素方面差异有统计学意义(P<0.05)。2组患者在发作类型、性别、文化程度方面的差异无统计学意义(P>0.05)。根据单因素分析结果,对年龄、病程、脑电图及头颅影像学检查结果、家庭因素4个因素进行Logistic回归分析。结论帕金森病患者的预后受临床及家庭关系的共同影响。除受年龄不可控影响,家庭关系极端型是帕金森病患者预后差的独立危险因素,应进一步加强干预。

Objective To observe the Hohn-Yahr rating scale(amendment)of newly-diagnosed Parkinson's disease patients after 1 year of treatment,explore the factors affecting the prognosis of patients with Parkinson's disease.Methods 105 newly-diagnosed Parkinson's disease patients in The People's Hospital of Leshan from November 1,2014 to November 1,2016 were selected and have follow-up visits for more than a year.A detailed record of patients’gender,age,level of education,course of disease,seizure type,results of EEG and craniography and family factors.Establish database by Excel,univariate analysis and Logistic regression analysis are applied for predicting prognostic factors in patients with Parkinson's disease(P<0.05).is statistically significant.Results the remission rate of patients in this group is 51%after 1 year treatment(Hoehn-Yahr rating scale of patients after one year treatment<3 are classified as remission group).In univariate analysis,there are significant differences in age,course of disease,the result of EEG and craniography,family factors between remission group and non-remission group(P<0.05).There was no significant difference in gender,education level and seizure type between the two groups(P>0.05).Logistic regression analysis was carried out for age,course of disease,EEG and head imaging findings,and family factors according to univariate analysis.Conclusion The prognosis of patients with Parkinson's disease is influenced not only by clinical factors,but also by family factors,intervention should be further enhanced.