逍遥散加减治疗肝郁脾虚型骨关节炎临床观察

Clinical Observation of Xiaoyao Powder on Osteoarthritis of Liver Depression and Spleen Deficiency Syndrome

目的观察逍遥散加减治疗肝郁脾虚型骨关节炎的临床疗效。方法研究对象为2018年1月-2019年7月湖南中医药大学第二附属医院关节科门诊及住院部肝郁脾虚型骨关节炎患者60例,随机分为两组各30例。两组均常规理疗,治疗组在常规理疗基础上予以内服逍遥散:柴胡10 g,当归10 g,白芍15 g,茯苓10 g,白术10 g,薄荷6 g,甘草5 g,随证加减。1剂/d,水煎服,早晚餐后30 min各服用1次。对照组在常规理疗基础上予以口服盐酸氨基葡萄糖,0. 75 g/次,2次/d。观察并比较两组治疗前后视觉模拟评分法(VAS)评分、WOMAC骨性关节炎指数评分及2组治疗后的临床疗效。结果治疗4周后发现,①两组治疗均能改善患者症状,总有效率治疗组优于对照组(P <0. 05)。②两组治疗前后组内比较及治疗后组间VAS评分相比较,差异均具有统计学意义(P <0. 05)。③两组治疗前后组内比较及治疗后组间WOMAC评分比较,差异均有统计学意义(P <0. 05)。结论逍遥散加减治疗肝郁脾虚型骨关节炎具有较好的临床疗效。

Objective To observe the clinical effect of Xiaoyao Powder on osteoarthritis of liver depression and spleen deficiency syndrome. Methods The subjects of this study were 60 patients with osteoarthritis of liver depression and spleen deficiency syndrome from January 2018 to July 2019,and 30 patients in each group. Two groups were given routine physical therapy. The treatment group on the basis of routine physical therapy took Xiaoyao Powder orally,one dose per day,30 minutes after breakfast and dinner. The control group was given oral Glucosamine 0. 75 g twice a day on the basis of routine physiotherapy. Visual analogue scale (Vas) scores,WOMAC osteoarthritis index scores and the clinical effects of the two groups were observed and compared before and after treatment. Results After 4 weeks of treatment,the total effective rate of the treatment group and the control group was 90. 0% and 83. 3% respectively. The total effective rate of the two groups was significantly different (P < 0. 05). There was significant difference in VAS scores between the two groups before and after treatment (P <0. 05). The comparison between the two groups before and after treatment and the comparison of WOMAC scores between the groups after treatment showed statistically significant differences (P < 0. 05). Conclusion Xiaoyao Powder has good clinical effect on treating osteoarthritis of liver depression and spleen deficiency syndrome.