神经肌肉电刺激辅助治疗对脑梗死患者脑部血流、CXC型趋化因子配体16及神经细胞因子的影响

Effect of neuromuscular electrical stimulation as an adjuvant therapy on cerebral blood flow,CXC chemokine ligand 16,and neurocytokines in patients with cerebral infarction

目的探究神经肌肉电刺激辅助治疗对脑梗死患者脑部血流、CXC型趋化因子配体16 (CXCL16)及神经细胞因子的影响。方法收集2017年12月至2018年12月西安国际医学中心医院收治脑梗死患者232例,随机分为观察组、对照组,每组各116例。两组均接受常规药物治疗及康复训练,观察组加用神经肌肉电刺激辅助治疗。比较两组患者的神经细胞因子、认知及综合功能、脑部血流和CXCL16、CD40配体(CD40L)水平。结果治疗后,两组的蒙特利尔认知评估量表(Mo CA)、功能综合评定量表(FCA)评分、脑源性神经营养因子(BDNF)水平、大脑前动脉、中动脉平均血流速度升高,且观察组高于对照组(P <0. 05)。治疗后,两组的神经元特异性烯醇化酶(NSE)、CXCL16、CD40L水平均降低,且观察组低于对照组(P <0. 05)。结论在常规治疗基础上应用神经肌肉电刺激治疗脑梗死,可有效修复脑组织损伤,加强脑部血流灌注,进而改善患者认知及综合能力。

Objective To investigate the effect of neuromuscular electrical stimulation as an adjuvant therapy on cerebral blood flow,CXC chemokine ligand 16(CXCL16),and neurocytokines in patients with cerebral infarction.Methods A total of 232 patients with cerebral infarction admitted to Xi’an International Medical Center Hospital from December 2017 to December 2018 were enrolled in this study and randomly divided into observation group(n=116)and control group(n=116).Both groups were treated with routine medication and rehabilitation training,and the observation group was given neuromuscular electrical stimulation as an adjuvant therapy additionally.The two groups were compared in terms of the levels of neurocytokines,cognitive and comprehensive functions,cerebral blood flow,CXCL16,and CD40 ligand(CD40L).Results After treatment,both groups showed increased scores of Montreal Cognitive Assessment and Functional Comprehensive Assessment,level of brain-derived neurotrophic factor,and mean blood flow velocity of anterior cerebral artery and medium-sized artery,and the observation group had significantly higher values than the control group(P<0.05);in addition,both groups showed reduced levels of neuron-specific enolase,CXCL16,and CD40L,and the observation group had significantly lower values than the control group(P<0.05).Conclusions On the basis of routine treatment,the adjuvant therapy of neuromuscular electrical stimulation in treating cerebral infarction can effectively repair brain tissue injury,strengthen cerebral blood·136·Journal of International Neurology and Neurosurgery 2020,47(2)perfusion,and thereby improve the cognitive and comprehensive abilities of patients.