克服肿瘤多药耐药的药物共递送纳米载体的设计及研究新方向

Advance in the Design and Development of Nanocarrier-mediated Co-delivery for Overcoming Multidrug-resistant Cancer

多药耐药(multidrug resistance,MDR)是肿瘤治疗成功的主要障碍,药物共递送纳米载体因其肿瘤靶向、控制释放、一致的药动学曲线而被认为是克服MDR的有效策略。本综述总结了当前克服MDR的药物共递送纳米载体的设计思路,并分析了具有前景的研究方向,包括精确药物负载纳米载体、呈时序释放的纳米载体和对肿瘤微环境设计纳米载体,这些新兴策略为临床肿瘤治疗提供了新颖且更好的定制组合方案。

Multidrug resistance(MDR) is a major obstacle to successful cancer treatment. Nanocarrier-mediated co-delivery is an effective strategy for overcoming MDR, which possess great advantages for tumor targeting, controlled drug release, and identical drug PK profiles. In this review, a summary of various design strategy of nanocarrier-mediated co-delivery was presented, and highlighted the recent advances in nanocarrier-mediated co-delivery against cancer drug resistance, including co-encapsulation of drugs with ratiometric control over drug loading, temporal sequencing on drug release, and tumor microenvironment. These emerging strategies promise novel and better tailored combinatorial regimens for clinical cancer treatment.