UA、TBiL、NGF水平在双相情感障碍、精神分裂症及健康人群中的检测价值分析

Study on the detection value of UA,TBiL and NGF levels in bipolar disorder,schizophrenia and healthy people

目的探讨血清神经生长因子(NGF)、总胆红素(TBiL)、尿酸(UA)在双相情感障碍、精神分裂症及健康人群中的检测价值。方法选取我院133例双相情感障碍患者设为研究组,同期133例精神分裂症患者设为对照组、133例健康体检者设为健康组。入院后抽取血液样本,测定NGF、TBiL、UA水平。统计分析3组血清UA、TBiL、NGF水平、双相情感障碍发病影响因素、不同病情程度(抑郁及躁狂)患者血清指标水平及[抑郁程度(HAMD)、躁狂程度(YMRS)]评分、血清指标与病情程度关联性,并分析其诊断效能。结果研究组UA高于对照组、健康组,TBiL、NGF低于对照组、健康组(P<0.05);UA、TBiL、NGF均为双相情感障碍发病重要影响因素(P<0.05);不同抑郁及不同躁狂程度者血清指标、HAMD、YMRS评分存在显著差异,且随抑郁及躁狂程度增加,UA、HAMD及YMRS呈增高趋势,TBiL、NGF呈降低趋势(P<0.05);UA与抑郁、躁狂程度呈正相关,TBiL、NGF与抑郁、躁狂呈负相关(P<0.05);NGFAUC为0.783,大于UA(0.645)、TBiL(0.651),当截断值≤43.74,其诊断敏感度为67.67%、特异度为78.95%。结论双相情感障碍患者UA、TBiL、NGF血清表达水平较精神分裂症患者及健康人群异常增高,并且与病情程度具有显著关联性,可能对双相情感障碍的诊断和病情程度评判具有一定价值。

Objective To investigate the detection value of serum nerve growth factor(NGF),total bilirubin(TBiL),and uric acid(UA)in bipolar disorder,schizophrenia and healthy people. Methods A total of 133 patients with bipolar disorder were enrolled in the study group. In the same period,133 patients with schizophrenia were selected as the control group and 133 healthy subjects were selected as the healthy group. Blood samples were taken after admission and the levels of NGF,TBiL,and UA were measured. Statistical analysis of serum UA,TBiL,NGF levels,factors affecting the onset of bipolar disorder,serum index levels and [degree of depression(HAMD),mania(YMRS)] scores in patients with different levels of disease(depression and mania),Serum indicators were correlated with disease severity and analyzed for diagnostic efficacy. Results The UA of the study group was higher than that of the control group and the healthy group. The TBiL and NGF were lower than the control group and the healthy group(P<0.05). UA,TBiL and NGF were all important factors affecting the incidence of bipolar disorder(P<0.05). There were significant differences in serum index,HAMD and YMRS scores between depression and different levels of mania. With the increase of depression and mania,UA,HAMD and YMRS showed an increasing trend,and TBiL and NGF showed a decreasing trend(P<0.05). UA and There was a positive correlation between depression and mania. TBiL and NGF were negatively correlated with depression and mania(P<0.05). NGFAUC was 0.783,which was greater than UA(0.645)and TBiL(0.651). When the cutoff value was less than or equal to 43.74,the diagnostic sensitivity was It is 67.67% and the specificity is 78.95%. Conclusions The serum levels of UA,TBiL and NGF in patients with bipolar disorder are abnormally higher than those in patients with schizophrenia and healthy people. It has a significant correlation with the degree of illness,and may have certain value in the diagnosis and assessment of bipolar disorder.