贝那普利联合氨氯地平对高血压患者降压效果、血压变异性及心功能的影响

Effect of Benazepril Combined with Amlodipine on Blood Pressure Reduction Effect, Blood Pressure Variability and Cardiac Function in Patients with Hypertension

目的:探讨贝那普利联合氨氯地平对高血压患者降压效果、血压变异性(BPV)及心功能的影响。方法:选取2015年2月~2018年12月期间西安交通大学医学院附属三二〇一医院收治的131例高血压患者,根据随机数字表法分为对照组(n=65)和研究组(n=66),对照组患者给予氨氯地平治疗,研究组在对照组基础上联合贝那普利治疗。比较两组患者治疗后的降压效果、BPV以及心功能指标,记录两组患者治疗期间不良反应情况。结果:两组患者治疗4个月后收缩压(SBP)、舒张压(DBP)均下降,且研究组低于对照组(P<0.05)。两组患者治疗4个月后24 h收缩压变异性(24hSBPV)、白天收缩压变异性(dSBPV)、24h舒张压变异性(24hDBPV)、白天舒张压变异性(dDBPV)均下降,且研究组低于对照组(P<0.05),而夜间收缩压变异性(nSBPV)、夜间舒张压变异性(nDBPV)比较差异无统计学意义(P>0.05)。两组患者治疗4个月后A峰速度、A/E峰值均下降,且研究组低于对照组(P<0.05)。两组患者治疗4个月后E峰速度、EF值均升高,且研究组高于对照组(P<0.05)。两组不良反应发生率比较无差异(P>0.05)。结论:贝那普利联合氨氯地平治疗高血压患者的降压效果确切,可有效改善患者BPV及心功能,且安全性较好。

Objective: To investigate the effect of benazepril combined with amlodipine on blood pressure reduction effect, blood pressure variability(BPV) and cardiac function in patients with hypertension. Methods: 131 hypertensive patients who were admitted to3201 Hospital Affiliated to Medical College of Xi’an Jiaotong University from February 2015 to December 2018 were selected as the research subjects. All patients were divided into control group(n=65) and study group(n=66) according to random number table method.The control group was treated with amlodipine, and the study group was treated with benazepril on the basis of the control group. The blood pressure reduction effect, BPV and cardiac function were compared between the two groups, and adverse reactions during treatment were recorded between the two groups. Results: 4 months after treatment, systolic blood pressure(SBP) and diastolic blood pressure(DBP) decreased in both groups, and those in the study group were lower than those in the control group(P<0.05). 24 h systolic blood pressure variability(24 hSBPV), daytime systolic blood pressure variability(dSBPV), 24 h diastolic blood pressure variability(24 hDBPV),daytime diastolic blood pressure variability(dDBPV) of the two groups decreased at 4 months after treatment, and those of the study group were lower than those of the control group(P<0.05). There was no significant difference in night systolic pressure variability(n SBPV) and night diastolic pressure variability(nDBPV)(P>0.05). 4 months after treatment, A peak velocity and A/E peak of the two groups decreased, and those of the study group were lower than those of the control group(P<0.05). The E peak velocity and EF value of the two groups increased at 4 months after treatment, and those of the study group were higher than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Benazepril combined with amlodipine in the treatment of hypertension has definite antihypertensive effect, it can effectively improve BPV and cardiac function, and it does not increase the incidence of adverse reactions, and the safety is better.