硫辛酸对阻塞性睡眠呼吸暂停低通气综合征患者睡眠呼吸情况及相关生化指标的影响

Effects of Lipoic Acid on Sleep Respiration, Relevant Biochemical Indexes in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

目的:探讨硫辛酸对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者睡眠呼吸情况及相关生化指标的影响。方法:选取石家庄市第一医院收治的OSAHS患者60例,采用随机数字表法分为对照组(n=30)和观察组(n=30)。对照组给予常规治疗,观察组在对照组基础上口服硫辛酸胶囊,疗程为12周。对比两组患者的临床疗效、爱泼沃斯嗜睡量表(ESS)评分,睡眠呼吸情况、糖脂代谢、肝功能及氧化应激指标水平。结果:与对照组比较,观察组治疗后的有效率升高,ESS评分降低(P<0.05)。与对照组比较,观察组治疗后呼吸暂停低通气指数(AHI)、脉压(PP)降低,最长呼吸暂停时间缩短,血氧饱和度(SaO2)水平升高(P<0.05)。与对照组比较,观察组治疗后空腹血糖、餐后2 h血糖、谷草转氨酶(AST)、甘油三酯(TG)、谷丙转氨酶(ALT)、总胆固醇(TC)、碱性磷酸酶(ALP)、丙二醛(MDA)水平降低,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)水平升高(P<0.05)。结论:采用硫辛酸治疗OSAHS患者具有较好的临床疗效,能够改善患者睡眠呼吸情况及肝功能,调节糖脂代谢,降低氧化应激反应。

Objective: To investigate the effect of lipoic acid on sleep respiration, relevant biochemical indexes in patients with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods: 60 OSAHS patients admitted to Shijiazhuang First Hospital were selected, they were divided into control group(n=30) and observation group(n=30) by random number table method. The control group were given routine treatment, while the observation group were given lipoic acid capsule orally on the basis of the control group, the course of treatment were 12 weeks. The clinical efficacy, Epworth sleepiness scale(ESS) scores, sleep respiration, glycolipid metabolism, liver function, oxidative stress levels were compared between the two groups. Results: Compared with the control group, the effective rate in the observation group were higher, ESS scores were lower after treatment(P<0.05). Compared with the control group, the apnea hypopnea index(AHI), pulse pressure(PP) were lower, maximum apnea time were shorter, blood oxygen saturation(SaO2) levels were higher in the observation group after treatment(P<0.05). Compared with the control group, the levels of fasting blood glucose, 2 h postprandial blood glucose, aspartate transaminase(AST), triacylglycerol(TG), alanine transaminase(ALT), total cholesterol(TC), alkaline phosphatase(ALP), malondialdehyde(MDA) were lower, the levels of superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) were higher in the observation group after treatment(P<0.05). Conclusion: Lipoic acid has a good clinical effect in the treatment of OSAHS, it can improve the sleep breathing and liver function, regulate the metabolism of glucose and lipid, and reduce oxidative stress.