来曲唑联合尿促性素对多囊卵巢综合征不同体质指数患者促排结局的影响

Effect of letrozole combined with urotropin on the outcome of different body mass index patients with polycystic ovary syndrome

目的分析探讨来曲唑联合尿促性素对多囊卵巢综合征不同体质指数患者促排结局的影响。方法研究对象选取自2018年6月至2019年8月间就诊于乌鲁木齐市妇幼保健院生殖科及妇科内分泌科就诊的有生育要求的pcos不孕患者100例,根据2000年世界卫生组织(WHO)及有关肥胖研究专家对亚太地区制定的肥胖与超重标准将患者按体重指数分为正常体重组、超重组、肥胖组,三组采用相同的治疗方案,比较三组妇女的女性基础激素水平、三组妇女的女性代谢激素水平及实验指标以及临床指标。结果三组的FSH、LH、E2、PR水平比较差异较小,P> 0.05;三组的血清T水平存在较大差异,P <0.05;三组妇女的子宫内膜厚度差异不明显,FBG、EINS、HOMA水平以及治疗时间皆有明显差异,肥胖组明显高于超重组与正常体重者,P <0.05;三组的排卵率、多胎妊娠率、早期流产率皆无太大差异,P> 0.05;三组的妊娠率存在明显差异。结论随着体质指数的增长,排卵率与临床妊娠率会随之降低,肥胖患者的排卵率与妊娠率明显的低于其他组,而来曲唑联合尿促性素能够有效的促进患者基础激素水平控制,提高排卵率,降低流产率具有较高的使用价值。

Objective To analyze the effect of letrozole combined with urotropin on the outcome of different body mass index patients with PCOS. Methods 100 PCOS infertile patients with fertility requirements were selected from the reproductive department and Gynecological Endocrinology Department of Urumqi Maternal and Child Health Hospital from June 2018 to August 2019. According to the obesity and overweight standards set by the World Health Organization(WHO)and relevant obesity research experts in the Asia Pacific region in 2000, the patients were divided into the normal weight group, the super recombination group and the obesity group, and the three groups adopted the same treatment plan, and the basic hormone level of women in the three groups, the metabolic hormone level of women in the three groups, the experimental indicators and clinical indicators were compared. Results The differences of FSH, LH, E2 and PR levels among the three groups were small(P > 0.05);the serum T levels of the three groups were significantly different(P There was no significant difference in abortion rate(P > 0.05);there was significant difference in pregnancy rate among the three groups. Conclusion With the increase of body mass index, the ovulation rate and clinical pregnancy rate will decrease. The ovulation rate and pregnancy rate of obese patients are significantly lower than that of other groups. Letrozole combined with urotropin can effectively promote the control of basic hormone level of patients, improve ovulation rate and reduce the abortion rate, which has a higher use value.