期刊文献+

免疫组织化学在乳腺癌病理诊断中的作用 被引量:4

下载PDF
导出
摘要 目的探讨免疫组织化学在乳腺癌病理诊断中的作用。方法选择2018年4月至2019年5月医院收治的160例乳腺癌患者作为研究对象,以雌激素受体(ER)、孕激素受体(PR)均为阳性的80例患者作为ER+PR+组,以ER、PR均为阴性的80例患者作为ER-PR-组。两组均接受免疫组织化学检验,比较两组C-erbB-2阳性率、阴性率及腋窝淋巴结转移率。结果 ER+PR+组C-erbB-2阳性率低于ER-PR-组,差异有统计学意义(P<0.05);ER+PR+组C-erbB-2阴性率高于ER-PR-组,差异有统计学意义(P<0.05);ER-PR-组腋窝淋巴结转移率高于ER+PR+组,差异有统计学意义(P<0.05)。结论免疫组织化学在乳腺癌病理诊断中的应用价值较高,且可为临床诊断提供必要的依据。
作者 刘智慧
出处 《医疗装备》 2020年第9期54-56,共3页 Medical Equipment
  • 相关文献

参考文献6

二级参考文献64

  • 1田晓琦,牛昀,张同先,田素文,张巍,吕淑华.神经降压素受体1在乳腺癌组织中的表达及预后意义[J].肿瘤防治研究,2014,41(6):578-581. 被引量:2
  • 2周晓燕,胡玉莲,王刚平,王洪远,王玲,梅岚,林慧.免疫组化表达在乳腺癌前驱病变与微浸润性癌鉴别诊断中的应用[J].中国临床实用医学,2014(3):19-21. 被引量:5
  • 3Viale G,Regan MM,Maiorano E,et al.Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer:BIG 1-98[J].J Clin Oncol,2007,25(25):3846-3852.
  • 4Rhodes A,Jasani B,Balaton AJ,et al.Frequency of oestrogen and progesterone receptor positivity by immunohistochemical analysis in 7016 breast carcinomas:Correlation with patient age,assay sensitivity,threshold value,and mammographic screening[J].J Clin Pathol,2000,53(9):688-696.
  • 5Zhang Z,Wang J,Skinner KA,et al.Pathological features and clinical outcomes of breast cancer according to levels of oestrogen receptor expression[J].Histopathology,2014,65(4):508-516.
  • 6Harvey JM,Clark GM,Osbome CK,et al.Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer[J].J Clin Oncol,1999,17(5):1474-1481.
  • 7Elledge RM,Green S,Pugh R,et al.Estrogen receptor(ER)and progesterone receptor(PgR),by ligand-binding assay compared with ER,PgR and pS2,by immunohistocheniistiy in predicting response to tamoxifen in metastatic breast cancer:A Southwest Oncology Group study[J].Int J Cancer,2000,89?2):111-117.
  • 8Hammond ME,Hayes DF,Dowsett M,et al.American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer[J].J Clin Oncol,2010,28(16):2784-2795.
  • 9Wolff AC,Hammond ME,Schwartz JN,et al.American Society of Clinical Oncology/ College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer[J].J Clin Oncol,2007,25(1):118-145.
  • 10Goldhirsch A,Winer EP,Coates AS,et al.Personalizing the treatment of women with early breast cancer:highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2013[J].Ann Oncol,2013,24(9);2206-2223.

共引文献251

同被引文献25

引证文献4

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部