吉林市区生活方式 环境因素与帕金森病发病的相关因素分析

Analysis of factors related to lifestyle,environmental factors and the incidence of Parkinson's disease in Jilin area

目的探讨不同临床分型帕金森病(PD)患者的影响因素。方法采用病例对照研究的方法,选取2017-12—2019-12北华大学附属医院、吉林医药学院附属医院、吉林市中心医院确诊的PD患者177例,按照起病类型分为静止性震颤型及运动迟缓型,2组均记录详细年龄、性别、吸烟史、饮酒史、高血压史、糖尿病史、高尿酸血症史、高同型半胱氨酸血症史并进行比较。结果震颤型99例,运动迟缓型76例。震颤型、运动迟缓型帕金森病患者年龄比较,差异无统计学意义(P>0.05)。不同吸烟史、饮酒史PD患者临床分型比较,差异无统计学意义(P>0.05)。高血压史、糖尿病史与PD患者临床分型比较,差异无统计学意义(P>0.05)。高尿酸血症史、高同型半胱氨酸血症史与PD患者临床分型比较,差异无统计学意义(P>0.05)。结论帕金森病患者以运动迟缓型发病较多,各相关因素与帕金森病不同临床类型无明显相关性。

Objective To explore the influencing factors of patients with different clinical types of Parkinson's disease(PD).Methods Using a case-control study,177 PD patients diagnosed from December 2017 to December 2019 at the Affiliated Hospital of Beihua University,the Affiliated Hospital of Jilin Medical College,and the Central Hospital of Jilin were selected.They were classified into static tremor type according to the onset type.And bradykinesia,the two groups recorded detailed age,gender,smoking history,drinking history,history of hypertension,history of diabetes,history of hyperuricemia,history of hyperhomocysteinemia and comparison.Results There were 99 cases of tremor type and 76 cases of bradykinesia type.There was no significant difference in the age of patients with tremor type and bradykinetic Parkinson's disease(P>0.05).There were no significant differences in clinical classification of PD patients with different smoking and drinking history(P>0.05).There was no significant difference in the history of hypertension,diabetes,and clinical classification of patients with PD(P>0.05).There was no significant difference in the history of hyperuricemia and hyperhomocysteinemia with the clinical classification of patients with PD(P>0.05).Conclusion This survey showed that patients with Parkinson's disease are more likely to develop bradykinesia.There were no significant correlations between various related factors and different clinical types of Parkinson's disease.