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急性脑卒中外周血白细胞C反应蛋白的变化与短期预后的关系 被引量:5

The relationship between short-term prognosis and changes of white blood cells and C-reactive protein in patients with acute stroke
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摘要 目的分析急性脑卒中外周血白细胞、C反应蛋白的变化与短期预后的关系。方法纳入200例急性脑卒中患者,根据发病30 d后mRS评分分为预后良好组及预后不良组,分别收集其年龄、白细胞、红细胞分布宽度、纤维蛋白原、INR、血糖、糖化血红蛋白、白蛋白、同型半胱氨酸、C反应蛋白、尿酸、尿素氮等12项危险因素,进行单因素分析,对比2组间各项危险因素的差异。并通过多因素Logistic回归分析各危险因素与急性脑卒中短期预后的关系及对短期预后的预测效能。结果单因素分析结果显示,2组年龄、白细胞计数、纤维蛋白原、INR、血糖、C反应蛋白比较,差异有统计学意义(P<0.05);多因素分析结果显示,年龄、白细胞计数、C反应蛋白水平与急性脑卒中患者短期预后独立相关(P<0.05)。结论急性脑卒中患者年龄、白细胞计数和C反应蛋白与短期预后有关,是预测短期预后的重要指标。 Objective To analyze the relationship between the changes of white blood cells and c-reactive protein in peripheral blood and short-term prognosis of acute stroke.Methods In 200 cases of acute cerebral apoplexy patients,according to the disease prognosis of 30 days later mRS score prognosis can be divided into good and poor prognosis group,respectively collect age,white blood cells,red blood cell distribution width,fibrinogen,INR,blood sugar,glycosylated hemoglobin,albumin,homocysteine,CRP,uric acid,urea nitrogen,such as 12 risk factors,single factor analysis and comparison of various risk factors of the differences between two groups.Multivariate Logistic regression was used to analyze the relationship between risk factors and short-term prognosis of acute stroke.Results Univariate analysis showed significant differences in age,white blood cell count,fibrinogen,INR,blood glucose and c-reactive protein(P<0.05).The results of multivariate analysis showed that age,white blood cell count and c-reactive protein level were independently correlated with short-term prognosis of patients with acute stroke(P<0.05).Conclusion Age,white blood cell count and c-reactive protein in patients with acute cerebral apoplexy are related to short-term prognosis.
作者 胡萍 崔妙玲 蒋云 HU Ping;CUI Miaoling;JIANG Yun(Affiliated Hospital of Guilin Medical College,Guilin 541300,China;First Affiliated Hospital of Guangxi Medical University,Nanning 530000,China)
出处 《中国实用神经疾病杂志》 2020年第2期98-101,共4页 Chinese Journal of Practical Nervous Diseases
基金 广西急诊与医学救援人才小高地项目(编号:GXJZ201427)。
关键词 白细胞计数 C反应蛋白 急性脑卒中 短期预后 相互关系 White blood cell count C-reactive protein Acute stroke Short-term prognosis
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