血清ALP、LDH水平与乳腺癌患者复发转移的相关性

Correlation of Serum ALP and LDH Levels with the Recurrence and Metastasis in Patients with Breast Cancer

目的探讨血清碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)与乳腺癌患者复发转移的关系,并对其相关性进行分析。方法病例对照研究,于2016年2月至2020年1月收集中山大学孙逸仙纪念医院的79例Ⅱ~Ⅳ期乳腺癌患者的临床资料,均为女性,依据患者是否存在复发转移现象分为2组,对照组(未复发转移,40例)和观察组(复发转移,39例)。观察分析两组初诊的ALP及LDH水平及其与复发转移的相关性。结果观察组的ALP、LDH水平均较对照组高,差异有统计学意义(P<0.05);血清ALP、LDH水平与乳腺癌复发转移发生风险呈正相关性(r>0,P<0.05)。结论血清ALP、LDH水平与乳腺癌患者复发转移之间具有相关性,对通过检测其血清ALP、LDH水平变化情况,可提示乳腺癌患者是否存在复发转移,及时采取有效干预措施,以减少预后风险。

Objective To investigate the relationship of serum alkaline phosphatase(ALP)and lactate dehydrogenase(LDH)with the recurrence and metastasis in patients with breast cancer,and to analyze its correlation.Methods The case-control study was performed.The clinical data of 79 patients with stageⅡ-Ⅳbreast cancer in Sun Yat-Sen Memorial Hospital of Zhongshan University from February 2016 to January 2020 were collected,and all of them were female.The patients were divided into control group(no recurrence and metastasis,40 cases)and observation group(recurrence and metastasis,39 cases)according to whether the patients had recurrence and metastasis.The correlation of newly diagnosed ALP and LDH levels with the recurrence and metastasis in two groups was observed and analyzed.Results The levels of ALP and LDH in observation group were higher than those in control group(P<0.05);The levels of serum ALP and LDH were positively correlated with the recurrence and metastasis of breast cancer(r>0,P<0.05).Conclusion There is correlation between serum ALP and LDH levels and the recurrence and metastasis in breast cancer patients.The detection of changes in serum ALP and LDH levels can indicate whether breast cancer patients have recurrence and metastasis,and effective intervention measures should be taken in time to reduce the risk of prognosis.