影响幽门螺旋杆菌初治疗效的多因素分析

Multivariate Analysis of the Initial Therapeutic Effect of Helicobacter Pylori

目的探讨年龄、性别、文化程度、病程等多种因素对初次治疗幽门螺旋杆菌的多因素分析。方法随机选取2014年7月至2016年8月432例初次抗HP治疗的患者作为研究对象,通过对年龄、性别、文化程度、服药疗程等多方面进行统计分析。结果HP根除情况:<40岁、40~59岁和≥60岁三个年龄段中,男性和女性的HP根除率比较,差异均无统计学意义(P>0.05)。男性和女性在不同年龄段的HP根除率比较,差异均有统计学意义(P<0.05),60岁及以上患者的HP根除率高于其他年龄段患者。治疗依从性:<40岁、40~59岁和≥60岁三个年龄段患者的抗HP治疗依从性比较结果显示,60岁及以上患者完全依从的比例高于其他年龄段患者,依从性较差的比例低于其他年龄段患者,差异有统计学意义(P<0.05)。结论年龄大、文化程度高的患者依从性更高。

Objective To compare efficacy of multiple factors such as age、gender、education、duration in the fist-line treatment for Helicobacter pylori(HP)infection.Methods A total of 432 patients with HP positive from July 2014 to August 2016 were randomized to receive:clarithromycin,amoxicillin,pantoprazole or esomeprazole,HP status was rechecked by 14 C-urea breath test 1 month after the end of therapy.Results The gender among the three groups(<40 years old,40~59 years old and≥60 years old)were no different,but the female and male in the three groups were different,the eradication rate were significant(P<0.05).The compliance in the 60 years old group was higher than the others,the difference was significant(P<0.05).Conclusion The eradication rate was higher in the older and high lever education.