普拉克索治疗帕金森病运动并发症的临床效果观察

Observation on the Clinical Effect of Praxole in the Treatment of Motor Complications of Parkinson’s Disease

目的探讨普拉克索治疗帕金森病运动并发症的临床效果。方法纳入我院88例2017年5月至2018年2月帕金森病运动并发症患者。随机数字表分组,常规左旋多巴片治疗组采取常规药物治疗,常规左旋多巴片治疗联合普拉克索治疗组则采取常规药物加上普拉克索治疗。比较常规左旋多巴片治疗组、常规左旋多巴片治疗联合普拉克索治疗组效果;运动功能改善时间、住院时间;治疗前后患者UPDRS(帕金森病评定量表)各项评分以及总分;不良反应。结果常规左旋多巴片治疗联合普拉克索治疗组效果、运动功能改善时间、住院时间、UPDRS(帕金森病评定量表)各项评分以及总分相比较常规左旋多巴片治疗组更好,P<0.05。常规左旋多巴片治疗联合普拉克索治疗组不良反应和常规左旋多巴片治疗组无明显差异,P>0.05。结论常规药物加上普拉克索治疗帕金森病运动并发症的效果理想。

Objective To investigate the clinical effect of praxole in the treatment of motor complications of Parkinson’s disease.Methods 88 patients with motor complications of Parkinson’s disease were included in our hospital.The random number table was divided into two groups.The conventional levodopa treatment group received conventional drug therapy,and the conventional levodopa treatment combined with pramipexole treatment group received conventional drug plus pramipexole treatment.To compare the effects of conventional levodopa tablets treatment group,conventional levodopa tablets treatment combined with pramipexole treatment group;Duration of motor function improvement and hospitalization;UPDRS(Parkinson’s disease rating scale)before and after treatment and the total score;The adverse event.Results Compared with conventional levodopa tablets combined with pramipexole,the treatment group had better efficacy,motor function improvement time,length of hospital stay,UPDRS(Parkinson’s disease rating scale)scores and total scores,P<0.05.There was no significant difference in side effects between the conventional levodopa treatment group and the praxole treatment group(P>0.05).Conclusion The effect of praxole combined with conventional drugs in the treatment of motor complications of Parkinson’s disease is ideal.