lncRNA与胃癌临床特征相关性的meta分析

Meta analysis of the relationship between the lncRNA and clinical features of gastric cancer

目的研究胃癌患者长链非编码RNA(lncRNA)表达与胃癌临床特征及预后相关性。方法计算机检索PubMed、EMbase、Web of Science数据库,检索时间截至2019年4月。根据检索策略及纳入、排除标准对文献进行筛选,并提取相关资料数据。使用Stata软件进行meta分析。结果本研究最终纳入18篇文献。lncRNA高表达组患胃癌风险是低表达组的1.510倍(HR=1.510,95%CI:1.213~1.878,P=0.000)。meta分析结果显示文献存在发表偏倚。lncRNA表达水平与胃癌患者的TNM分期(HR=1.981,95%CI:1.458~2.692,P=0.000)、肿瘤分化程度(HR=1.273,95%CI:1.103~1.469,P=0.001)、浸润深度(HR=1.862,95%CI:1.565~2.216,P=0.000)、淋巴结转移(HR=1.570,95%CI:1.086~2.270,P=0.016)、远处转移(HR=2.581,95%CI:1.503~4.430,P=0.001)相关性明显。结论lncRNA与胃癌患者预后不良以及临床病理特征相关,可能成为胃癌患者预后以及病情监控的重要指标,但其临床应用价值还需在未来更多研究中予以证实。

Objective To study the correlation between long non-coding RNA(lncRNA)and gastric cancer and prognosis.Methods PubMed,EMbase and Web of Science database were searched,the search ended on April 2019.According to the retrieval strategy and inclusion and exclusion criteria,the literatures were screened and the relevant data were extracted.Stata software was used for meta analysis.Results Eighteen literatures were included in this study.The risk of gastric cancer in the group with high expression of lncRNA was 1.510 times than that of the group with low expression of lncRNA(HR=1.510,95%CI:1.213-1.878,P=0.000).Meta-analysis showed that there was publication bias in the literature.LncRNA expression level and TNM stage of gastric cancer patients(HR=1.981,95%CI:1.458-2.692,P=0.000),tumor differentiation degree(HR=1.273,95%CI:1.103-1.469,P=0.001),invasion depth(HR=1.862,95%CI:1.565-2.216,P=0.000),lymph node metastasis(HR=1.570,95%CI:1.086-2.270,P=0.016),and distant metastasis(HR=2.581,95%CI:1.503-4.430,P=0.001)were significantly correlated.Conclusion lncRNA is associated with poor prognosis and clinicopathological features in patients with gastric cancer,so it may be an important biomarker for gastric cancer patients.However,its clinical application still needs to be verified through more researches in the future.