血清PDCD5、PCNA表达与非小细胞肺癌患者临床病理特征及近期预后的关系

Relationship between serum PDCD5 and PCNA expression with clinicopathological characteristics and short-term prognosis in patients with non-small cell lung cancer

目的研究非小细胞肺癌(NSCLC)患者血清程序性细胞死亡5(PDCD5)及增殖细胞核抗原(PCNA)的表达及与近期预后的关系。方法选取2017年2月~2018年2月安徽省宿州市立医院诊治的NSCLC患者79例作为癌症组,以同期40名健康体检者作为对照组。应用酶联免疫吸附试验检测两组血清PDCD5、PCNA的表达水平。分析NSCLC患者PDCD5、PCNA表达与临床病理特征之间的关系。分析NSCLC患者PDCD5、PCNA不同表达水平与1年总生存期(OS)的关系。结果癌症组血清PDCD5表达水平低于对照组,而PCNA表达水平高于对照组,差异有统计学意义(均P<0.05)。血清PDCD5、PCNA表达与TNM分期、淋巴结转移有关(均P<0.05)。血清PDCD5与PCNA表达呈显著负相关(r=-0.621,P=0.000)。低PDCD5表达患者1年OS低于高PDCD5表达患者(P<0.05);高表达PCNA患者1年OS低于低PCNA表达患者(P<0.05)。结论NSCLC患者血清PDCD5表达降低,PCNA表达升高,二者与TNM分期、淋巴结转移有关,有希望成为新的NSCLC血清肿瘤标志物。

Objective To study the expressions of programmed cell death 5(PDCD5)and proliferating cell nuclear antigen(PCNA)in serum of patients with non-small cell lung cancer(NSCLC)and their relationship with the short-term prognosis.Methods From February 2017 to February 2018,79 cases with NSCLC patients who diagnosed and treated in Suzhou Municipal Hospital of Anhui Province were selected as cancer group,and 40 healthy medical examinees in the same period were used as control group.Enzyme-linked immunosorbent assay was used to detect the expression of PDCD5 and PCNA in the serum of two groups.The relationship between PDCD5,PCNA expression and clinicopathological characteristics of NSCLC patients were analyzed.The relationship between different levels of PDCD5 and PCNA expressions and the 1-year overall survival(OS)rate in NSCLC patients were analyzed.Results The expression levels of PDCD5 in cancer group were lower than those in control group,while the expression levels of PCNA in cancer group were higher than those in control group,and the difference was statistically significant(P<0.05).The expressions of PDCD5 and PCNA in serum of the cancer group were related to TNM stage and lymph node metastasis(P<0.05).Serum PDCD5 was significantly negatively correlated with PCNA expression(r=-0.621,P=0.000).Patients with low PDCD5 expression had lower OS than patients with high PDCD5 expression for 1-year(P<0.05).The 1-year OS of patients with high PCNA expression was lower than that of patients with low PCNA expression(P<0.05).Conclusion The expression of serum PDCD5 of NSCLC patients is decreased,while the expression of PCNA is increased,which are related to the staging of TNM and lymph node metastasis,and are expected to become a new tumor marker in NSCLC serum.