呼气试验对胃排空延迟诊断价值的meta分析

Diagnostic accuracy of breath test in detection of delayed gastric emptying:a meta-analysis

目的评估呼气试验对胃排空延迟的诊断价值。方法检索PubMed、the Cochrane library、中国知网、万方、维普、中国生物医学文献等数据库,搜集国内外关于呼气试验诊断胃排空延迟的诊断性试验,检索时间均为建库至2018年4月。采用固定效应模型进行荟萃分析,研究指标包括敏感度、特异度、阳性似然比、阴性似然比、诊断比值比以及曲线下面积(AUC)。结果共纳入10项研究涉及434名研究对象。呼气试验对延迟胃排空的鉴别诊断敏感度为0.826(95%CI:0.728~0.894),特异度为0.876(95%CI:0.800~0.925),AUC为0.92。阳性似然比为6.640(95%CI:3.987~11.060),阴性似然比为0.198(95%CI:0.122~0.321)。结论呼气试验在胃排空延迟中有较高诊断价值,期待在临床进一步推广应用。

Objective To evaluate the diagnostic value of breath test for delayed gastric emptying.Methods Database include PubMed,the Cochrane Library,China National Knowledge Internet,WanFang Data,VIP,CBM were searched to collect exsiting diagnostic accuracy tests on delayed gastric emptying diagnosed,the retrieval time was from database construction to April 2018.The fixed effect model was used for meta-analysis,and the research indicators included sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,diagnostic odds ratio and the area under the curve(AUC).Results Ten studies with 434 objects were included.The sensitivity of breath test for diagnosis of delayed gastric emptying was 0.826(95%CI:0.728 to 0.894),and the specificity was 0.876(95%CI:0.800 to 0.925).The AUC was 0.92.The combined positive likelihood ratio was 6.640(95%CI:3.987 to 11.060),and the negative likelihood ratio was 0.198(95%CI:0.122 to 0.321).Conclusion Breath test is a useful tool for detecting delayed gastric emptying with a relatively high sensitivity and specificity.It is expected to be applied in clinic.