外周血T淋巴细胞亚群及血清IL-6在血液病脓毒血症儿童中的诊断价值分析

The Diagnostic Value of Peripheral Blood T Lymphocyte Subsets and Serum IL-6 in Children with Sepsis

目的探讨血液病脓毒血症儿童外周血T淋巴细胞亚群及血清IL-6表达水平的变化及意义。方法将2013年10月至2019年10月本院小儿血液肿瘤科收治的220例血液病脓毒血症患儿作为脓毒血症组,140例无感染血液病患儿作为对照组;脓毒血症组内合并感染性休克的患儿50例作为休克组,脓毒血症组内无感染性休克的患儿170例为无休克组。回顾性分析这些患儿的外周血T淋巴细胞亚群及血清IL-6水平。结果脓毒血症组患儿血清IL-6水平及外周血CD3+CD8+Ts淋巴细胞数量较对照组明显升高;外周血CD3+T淋巴细胞及CD3+CD4+Th淋巴细胞数量较对照组明显下降,差异均有统计学意义(P<0.05)。同时证实,血液病脓毒血症患儿的外周血CD3+CD8+Ts细胞及血清IL-6与脓毒血症患者严重程度呈正相关性,当二者同时显著升高时,患儿更容易发生脓毒血症休克。结论外周血T淋巴细胞亚群及血清IL-6在血液病脓毒血症患儿中呈现异常表达的状态,且与病情严重程度有密切的关系,因此有较高的检测价值。

Objective To investigate the changes and significances of T lymphocyte and IL-6 expressions in peripheral blood and serum in children with Sepsis.Methods From October,2013 to October,2019,220 children with sepsis were selected as the sepsis group,while 140 children without infections were selected as the control group.There were 50 children with septic shock and 170 children without septic shock in the sepsis group.The levels of T lymphocyte and IL-6 in peripheral blood of these children were analyzed retrospectively.Results The levels of IL-6 and CD3+CD8+Ts in the peripheral blood of the children with sepsis were significantly higher than those in the control group,while the levels of CD3+T lymphocyte and CD3+CD4+Th lymphocyte in the peripheral blood were significantly lower than those in the control group(P<0.05).Moreover,the positive correlation between CD3+CD8+Tscell and IL-6 was found in children with sepsis.When the level of CD3+CD8+Ts cells and IL-6 increased significantly at the same time,the children were more prone to have a septic shock.Conclusion The abnormal expressions of T lymphocyte and serum IL-6 in children with hematologic disease complicated with sepsis are closely related to the severity of the disease,suggesting a high detection value.