盐酸贝尼地平、缬沙坦联合吲达帕胺治疗顽固性高血压的的临床效果

Clinical Effect of Combination of Benidipine Hydrochloride,Valsartan and Indapamide on Refractory Hypertension

目的探讨盐酸贝尼地平、缬沙坦联合吲达帕胺治疗顽固性高血压的临床效果。方法选取顽固性高血压患者62例,按随机数字表法分为2组:对照组32例,予以盐酸贝尼地平+缬沙坦+氢氯噻嗪治疗;观察组30例,予以盐酸贝尼地平+缬沙坦+吲达帕胺治疗。比较2组临床疗效,治疗前后血压及相关生化指标水平变化情况。结果与对照组比较,观察组治疗总有效率显著增高,治疗后血压(收缩压、舒张压)显著降低,相关生化指标(血肌酐和尿素氮)水平显著降低,差异均有统计学意义(均P<0.05)。结论盐酸贝尼地平、缬沙坦联合吲达帕胺治疗顽固性高血压,降压效果显著,且能明显改善患者肾功能。

Objective To investigate the clinical efficacy of benidipine hydrochloride combined with valsartan and indapamide in the treatment of refractory hypertension.Methods Sixty-two patients with refractory hypertension were randomly treated with either benidipine hydrochloride+valsartan+hydrochlorothiazide(control group,32 patients)or benidipine hydrochloride+valsartan+indapamide(observation group,30 patients).Clinical efficacy,blood pressure and biochemical indexes were compared between the two groups.Results Compared with control group,the total effective rate was increased and the systolic blood pressure,diastolic blood pressure and levels of serum creatinine and urea nitrogen were decreased in observation group after treatment(P<0.05).Conclusion The combined treatment with benidipine hydrochloride,valsartan and indapamide can effectively lower blood pressure and improve kidney function in patients with refractory hypertension.