重组人干扰素-α1b注射液治疗儿童疱疹性咽峡炎的效果

Effect of Recombinant Human Interferon-α1b Injection on Herpes Angina in Children

目的探讨重组人干扰素-α1b注射液治疗儿童疱疹性咽峡炎的效果。方法将124例儿童疱疹性咽峡炎患儿按随机数字表法分为观察组和对照组,每组62例。2组常规治疗:静脉滴注单磷酸阿糖腺苷和口腔护理;对照组加用利巴韦林喷剂治疗,观察组加用重组人干扰素α-1b注射液治疗,共治疗5 d。比较2组疗效、临床症状和体征改善时间以及不良反应发生情况。结果观察组总有效率为95.16%,高于对照组的80.65%(P<0.05);观察组患儿的退热、疱疹消失、恢复进食、咽痛消失及住院所需时间均较对照组短(P<0.05);观察组1例(1.61%)、对照组2例(3.23%)出现躯干皮疹,2组比较差异无统计学意义(P>0.05)。结论在常规治疗的基础上,加用重组人干扰素-α1b注射液对儿童疱疹性咽峡炎效果较好,可以更快地改善患儿临床症状。

Objective To investigate the therapeutic effect of recombinant human interferon-α1b injection on herpes angina in children.Methods A total of 124 children with herpes angina were treated with intravenous infusion of adenosine monophosphate and oral care.In addition,these children were randomly assigned to receive either ribavirin spray(control group,n=62)or recombinant human interferonα-1b injection(observation group,n=62)for 5 days.The efficacy,clinical symptoms,sign improvement time and adverse reactions were compared between the two groups.Results The total effective rate in observation group(95.16%)was higher than that in control group(80.65%)(P<0.05).Furthermore,the time to fever abatement,herpes disappearance,food intake resumption and pharyngalgia disappearance and the length of hospital stay in observation group were shorter than those in control group(P<0.05).There was no significant difference in the incidence of rash on trunk between observation group(1.61%,1 case)and control group(3.23%,2 cases)(P>0.05).Conclusion On the basis of conventional treatment,recombinant human interferon-α1b injection can effectively and quickly improve clinical symptoms in children with herpes angina.