摘要
目的探讨健脾和胃方颗粒结合常规西药治疗脾虚气滞型慢性非萎缩性胃炎(chronic non-atrophic gastritis,CNAG)的疗效及对患者症状、心理及免疫状态的影响。方法选择2018年6月—2019年4月于温州市中医院确诊并行治疗的脾虚气滞型慢性非萎缩性胃炎患者97例,按照随机数字表法将患者分为联合组(48例)及对照组(49例)。所有患者确诊后均行幽门螺杆菌检查,阳性患者予以雷贝拉唑+阿莫西林+克拉霉素+胶体果胶铋四联疗法,而阴性患者则予以雷贝拉唑+胶体果胶铋,治疗时间为2周。而联合组在此基础上加用健脾和胃方颗粒剂。比较2组患者治疗后的疗效,治疗前后症状评分、心理功能评分、免疫功能指标以及不良反应发生率。结果治疗后,联合组疗效优于对照组(P<0.05)。治疗后联合组胃镜病理评分优于对照组(Z=4.370,P=0.038)。治疗后联合组患者HAMA及HAMD评分为(8.74±1.19)分、(8.03±1.14)分,低于对照组的(11.32±2.47)分、(11.04±2.98)分(t=-6.531、-6.544;均P<0.05)。治疗后联合组患者NK、CD3^+、CD4^+、CD8^+及CD4^+/CD8^+比例均高于对照组(均P<0.05)。2组患者各类不良反应发生情况比较差异无统计学意义(均P>0.05)。结论健脾和胃颗粒剂辅助治疗脾虚气滞型CNAG患者,在提升疗效的同时,还能进一步改善患者焦虑及抑郁情绪,提升免疫功能,安全性也较好。
Objective To investigate the effects of Jianpi Hewei Granule combined with conventional western medicine on symptoms,psychology and immune status in patients with chronic non-atrophic gastritis of spleen deficiency and Qi stag-nation.Methods A total of 97 patients with spleen-deficiency Qi stagnation type CNAG who were diagnosed in our hos-pital from June 2018 to April 2019 were enrolled.All patients were divided into a combination group(48 cases)and a control group(49 cases)according to the random number table method.All patients underwent Helicobacter pylori exam-ination after diagnosis.The positive patients received rabeprazole+amoxicillin+clarithromycin+colloidal pectin quad-ruple therapy,while the negative patients received rabeprazole+colloidal pectin.The treatment time was 2 weeks,and the combined group was given Jianpi Hewei Granules.The difference between the two groups of patients after treatment,the difference between symptom score,psychological function score,immune function index and adverse reaction rate be-fore and after treatment.Results After treatment,the combined group efficacy was better than the control group,the difference was statistically significant(P<0.05).After treatment,the combined gastroscope pathological score was bet-ter than the control group,the difference was statistically significant(Z=4.370,P=0.038).The HAMA score and HAMD scores of the patients in the combined group(8.74±1.19 and 8.03±1.14)were lower than those in the control group(11.32±2.47 and 11.04±2.98),and the difference was statistically significant(t=-6.531,-6.544;all P<0.05).The proportions of NK,CD3^+,CD4^+,CD8^+ and CD4^+/CD8^+ in the combined group were significantly higher than those in the control group(all P<0.05).There was no statistically significant difference in the occurrence of various adverse reactions between the two groups of patients(all P>0.05).Conclusion Jianpi Hewei Granules can be used to treat patients with spleen deficiency and Qi stagnation type CNAG.It can improve the patient's anxiety and de-pression,improve immune function and safety.
作者
黄晓映
曾耀明
何璠
HUANG Xiao-ying;ZENG Yao-ming;HE Pan(Department of Gastroenterology,Wenzhou Hospital of Traditional Chinese Medicine,Wenzhou,Zhejiang 325000,China)
出处
《中华全科医学》
2020年第7期1200-1203,共4页
Chinese Journal of General Practice
基金
浙江省中医药科技计划项目(2017ZKL019)。
关键词
慢性非萎缩性胃炎
脾虚气滞型
健脾和胃方
心理状态
免疫水平
Chronic non-atrophic gastritis
Spleen deficiency Qi stagnation
Spleen and stomach
Mental state
Immune level