表皮生长因子在鼓膜穿孔修复中的作用

Application of epidermal growth factor for the regeneration of tympanic membrane perforation

鼓膜穿孔是耳科门诊常见疾病之一,根据其病程长短,可简单分为急性鼓膜穿孔和慢性鼓膜穿孔。因鼓膜具有较强的自愈能力,小的创伤性鼓膜穿孔大多能够自愈,然而大的鼓膜穿孔往往愈合较慢或者迁延不愈,可演变成为慢性鼓膜穿孔。目前手术仍是治疗慢性鼓膜穿孔的主要方式,患者往往需要承担相应的手术风险,并支付较高的手术医疗费用。因此,寻求一个高效、微创、经济的替代疗法显得尤其重要。近年来,随着组织工程学的发展,涌现出许多新的材料与技术用于治疗各种类型的鼓膜穿孔,其中表皮生长因子被认为是一种能够有效促进鼓膜愈合的生物活性分子而备受关注。本文将对近年来表皮生长因子应用于鼓膜穿孔的研究成果进行总结。

Tympanic membrane perforation(TMP)is a common disease in the otology clinic.It is typically classified as acute and chronic TMP according to the duration of the perforation.Small traumatic TMPs tend to heal spontaneously and quickly while large TMPs may fail to heal and result in chronic perforations.Currently,surgery using various autografts is commonly used for the repair of chronic TMPs.However,surgery is expensive and time-consuming with associated high cost and surgical risks.Thus,a novel therapy is warranted which is effective,minimally invasive and economical.With the advances in tissue engineering,numerous bio-scaffolds and bioactive molecules have been applied with encouraging results.Among them,epidermal growth factor(EGF)is one of the most commonly used bioactive molecules.Hence,this article is intended to review the achievements in recent research for the application of EGF in TMP repair.