活性氧与恶性肿瘤的关系

Relationship between reactive oxygen species and malignant tumors

活性氧是一类活性较高的含氧化合物,能够在机体内发生氧化反应,正常生理条件下由抗氧化系统清除。氧化剂和抗氧化剂系统之间的不平衡导致活性氧的过度产生和积累,可造成胞内DNA、脂质及蛋白的氧化损伤,诱发细胞恶变可能。另外,活性氧还可作为信号分子通过参与调控不同的信号转导途径发挥双重作用,一方面诱导肿瘤细胞增殖,提高肿瘤细胞耐受性,促进肿瘤细胞转移;另一方面诱导肿瘤细胞的凋亡甚至坏死。由此可见活性氧与肿瘤的发生发展有着密切的联系,活性氧可作为肿瘤治疗的重要靶点。

Reactive oxygen species(ROS)are a kind of highly active oxygenated compounds,which can produce oxidative reactions in the body and be scavenged by the antioxidant system under normal physiological conditions.The imbalance between oxidant and antioxidant leads to excessive production and accumulation of reactive oxygen species,which can cause oxidative damage of DNA,lipid and protein in cells and induce malignant transformation of cells.In addition,ROS can also play a dual role as a signal molecule by participating in regulating different signal transduction pathways.On the one hand,ROS can induce the proliferation,improve tolerance and promote the metastasis of cancer cells;on the other hand,ROS can induce apoptosis or even necrosis of cancer cells.Therefore,ROS are closely related to the occurrence and development of tumors and can be used as an important target for cancer treatment.