百蕊颗粒联合阿奇霉素和布地奈德雾化吸入治疗MP感染合并CVA患儿的疗效及对肺功能的影响

Therapeutic Effect of Bairui Granule Combined with Azithromycin and Budesonide Aerosol Inhalation on Children with MP Infection Complicated with CVA and Its Effect on Pulmonary Function

目的:探讨百蕊颗粒联合阿奇霉素和布地奈德雾化吸入治疗肺炎支原体(MP)感染合并咳嗽变异性哮喘(CVA)患儿的疗效及对肺功能的影响。方法:选取2015年4月~2019年2月期间张家口学院附属人民医院收治的113例MP感染合并CVA患儿,采用随机数字表法将患儿随机分为研究组(n=57)和对照组(n=56),对照组患儿给予阿奇霉素和布地奈德雾化吸入治疗,研究组在对照组的基础上联合百蕊颗粒治疗,比较两组患儿临床疗效、临床症状缓解时间、肺功能指标及不良反应。结果:研究组的临床总有效率为89.47%(51/57),高于对照组患儿的67.86%(38/56)(x^2=7.892,P=0.005)。研究组治疗后哮鸣音消失时间、哮喘持续时间、咳嗽消失时间、咽痛消失时间、体温恢复正常时间均短于对照组(t=13.447、16.553、24.094、33.552、25.363,均P<0.05)。研究组治疗后第1s用力呼气容积(FEV1)、呼气流量峰值(PEF)、用力肺活量(FVC)、FEV1/FVC高于对照组(t=6.512、11.496、4.220、4.467,均P<0.05)。两组患儿不良反应发生率比较差异无统计学意义(x2=0.463,P=0.496)。结论:百蕊颗粒联合阿奇霉素和布地奈德雾化吸入治疗MP感染合并CVA患儿,疗效确切,可改善患儿的临床症状,同时还可改善患儿的肺功能,用药安全性较好,临床应用价值较高。

Objective:To investigate the therapeutic effect of Bairui granule combined with azithromycin and Budesonide aerosol inhalation on children with Mycoplasma pneumoniae(MP)infection complicated with cough variant asthma(CVA)and its effect on pulmonary function.Methods:113 children with MP infection complicated with CVA who were admitted to People’s Hospital Affiliated to Zhangjiakou College from April 2015 to February 2019 were selected,they were randomly divided into study group(n=57)and control group(n=56)according to the random number table method.The control group was treated with azithromycin and Budesonide aerosol inhalation.The study group was treated with Bairui granule on the basis of the control group.The clinical efficacy,clinical symptoms relief time,pulmonary function indicators and adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 89.47%(51/57),which was significantly higher than 67.86%(38/56)of the control group(x^2=7.892,P=0.005).The disappearance time of wheezing sound,asthma duration,cough disappearance time,pharyngalgia disappearance time and body temperature normal time of the study group were shorter than those of the control group after treatment(t=13.447,16.553,24.094,33.552,25.363;all P<0.05).The forced expiratory volume(FEV1),peak expiratory flow(PEF),forced vital capacity(FVC),FEV1/FVC of the study group were higher than those of the control group after treatment(t=6.512,11.496,4.220,4.467;all P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(x2=0.463,P=0.496).Conclusion:Bairui granule combined with azithromycin and Budesonide aerosol inhalation in the treatment of children with MP infection complicated with CVA has a definite curative effect.It can rapidly improve the clinical symptoms of the children,and it also improve the pulmonary function of the children.It has good safety and high clinical application value.