肠道菌群及其代谢产物与心血管疾病关系的研究进展

Progress in the relationship between intestinal flora and its metabolites with cardiovascular diseases

心血管疾病作为目前致死致残率较高的疾病,时刻威胁着人类的健康。近年来,随着研究的不断进展,有报道称肠道菌群及其代谢产物也参与到心血管疾病(包括与动脉粥样硬化、心力衰竭、高血压等)发生发展的过程中。通过改善肠道菌群及其代谢产物的组成,可以改善心血管疾病的进程,而这种治疗方法也成为了一个治疗心血管疾病的新方向。本文就肠道菌群的组成,肠道菌群代谢产物的作用,肠道菌群及其代谢产物与动脉粥样硬化、心力衰竭、高血压等疾病的关系,通过改善肠道菌群进行疾病治疗等的研究现状进行综述。

Cardiovascular disease,as a disease with high mortality and disability rates,is a constant threat to human health.In recent years,with the continuous development of research,it has been reported that intestinal flora and its metabolites are also involved in the occurrence and development of cardiovascular diseases(including atherosclerosis,heart failure and hypertension).By improving the composition of intestinal flora and its metabolites can improve the progression of cardiovascular diseases.This treatment has become a new target for the treatment of cardiovascular diseases.In this paper,the composition of intestinal flora,the role of intestinal flora metabolites and the relationship between intestinal flora and its metabolites and atherosclerosis,heart failure,hypertension and other diseases were reviewed.