TLR10和BIRC5基因多态性对甲状腺乳头状癌发病风险的影响

Impact of Toll-like receptor 10 and Baculoviral IAP repeat containing 5 gene polymorphisms on risk of papillary thyroid carcinoma

目的:探究TLR10和BIRC5基因的易感性与甲状腺乳头状癌(PTC)的关系。方法:通过使用Agena Mass ARRAY平台对4个单核苷酸多态性(SNP)(rs11466653、rs11096956、rs11096955、rs9904341)进行检测评估,并采用卡方检验、遗传模型分析以及单体型分析等统计分析方法。结果:rs11096956位点(TLR10)的等位基因"C"与rs9904341位点(BIRC5)的等位基因"G"均与增加PTC的发病风险相关(rs11096956:OR=1.26,95%CI=1.09~1.97,P=0.031;rs9904341:OR=1.26,95%CI=1.17~2.04,P=0.019)。在遗传模型下,通过逻辑回归分析发现在共显性模型、显性模型以及加性模型中rs11096956 SNPs位点的多态性与增加PTC的发病风险相关。在共显性模型和显性模型下,rs9904341位点的多态性与PTC风险增加有关。此外,TLR10基因的SNPs位点构成的单倍体型"Trs11466653Trs11096956Crs11096955"与增加PTC的发病风险有关。分层分析显示,rs11096956(TLR10)和rs9904341(BIRC5)位点多态性可显著增加女性PTC的发病风险(P<0.05)。结论:发现表明rs11096956(TLR10)和rs9904341(BIRC5)的变异与PTC风险的增加有关,尤其是在女性人群中。

Objective:To investigate the association between rs11096956(TLR10)and rs9904341(BIRC5)genes thatsusceptibleto the papillary thyroid carcinoma(PTC).Methods:Four single nucleotide polymorphism(SNP)genotypes(rs11466653,rs11096956,rs11096955 and rs9904341)were assessed by using the Agena Mass ARRAY platform,and statistical analyses were performed by using chi-square,genetic model analysis and haplotype analysis.Results:The allele"C"of rs11096956(TLR10)and allele"G"of rs9904341(BIRC5)were associated with an increased risk of PTC(rs11096956:OR=1.26,95%CI=1.09-1.97,P=0.031;rs9904341:OR=1.26,95%CI=1.17-2.04,P=0.019).In the genetic model,logistic regression analyses revealed that the rs11096956 polymorphism was conferred an increased risk of PTC in the codominant model,the dominant model,and the log-additive model.The rs9904341 polymorphism was associated with an increased risk of PTC in the codominant model and the dominant model.In addition,thehaplotype"Trs11466653 Trs11096956 Crs11096955"of TLR10 was found to be associated with an increased risk of PTC.Stratification analysis revealed that rs11096956(TLR10)and rs9904341(BIRC5)were able to significantly increase the risk of PTC in females(P<0.05).Conclusion:Our findings suggest that variations in rs11096956(TLR10)and rs9904341(BIRC5)areassociated with increased risk of PTC,particularly in the female.