滋水清肝饮对围绝经期抑郁症患者的临床疗效及对血清孤啡肽和5-羟色胺的影响

Clinical effect of Zishui Qinggan Decoction on patients with perimenopause depression and its effect on serum orphan enkephalin and 5-hydroxytryptamine

目的:探讨滋水清肝饮对围绝经期抑郁症患者的临床疗效及对血清孤啡肽和5-羟色胺的影响。方法:将2017年10月-2018年10月在承德市双滦区人民医院妇科治疗的86例围绝经期抑郁症患者随机分为两组,对照组采用黛力新治疗,观察组使用滋水清肝饮治疗,比较两组患者的临床疗效、血清孤啡肽和5-羟色胺变化、汉密顿抑郁量表(Hamilton Depression Scale,HAMD)评分变化。结果:观察组治疗总有效率为95.35%(41/43),明显高于对照组的79.07%(34/43)(P<0.05);观察组治疗后1个月、2个月、3个月的血清孤啡肽明显高于对照组,而5-羟色胺明显低于对照组(P<0.05);观察组治疗1个月、2个月、3个月的HAMD评分明显低于对照组(P<0.05)。结论:滋水清肝饮对围绝经期抑郁症患者的临床疗效显著,能有效缓解抑郁症状,能有效改善脑部神经递质水平,提高5-羟色胺含量,具有积极的临床意义。

Objective:To investigate the clinical effect of Zishui Qinggan Decoction(滋水清肝饮)on patients with perimenopause depression and its effect on serum orphan enkephalin and 5-hydroxytryptamine.Methods:86 patients with perimenopause depression who were treated in our hospital from October 2017 to October 2018 were randomly divided into two groups.The control group was treated with dilixin,and the observation group was treated with Zishui Qinggan Decoction.The clinical efficacy,changes in serum orphan enkephalin and 5-hydroxyserotonin,and changes in HAMD score were compared between the two groups.Results:The effective rate of treatment in the observation group was 95.35%(41/43),which was significantly higher than that in the control group 79.07%(34/43)(P<0.05).The serum levels of the treatment group were significantly higher than those of the control group 1,2 and 3 months after treatment,while the levels of 5-ht of the observation group were significantly lower than those of the control group(P<0.05).HAMD scores of the observation group 1,2 and 3 months after treatment were significantly lower than those of the control group(P<0.05).Conclusion:Zishui Qinggan Decoction has a significant clinical effect on patients with depression in perimenopian period,which can effectively relieve depressive symptoms,improve the level of neurotransmitter in brain and increase the content of 5-hydroxytryptamine,and it has positive clinical significance.